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| 1 | 自身免疫性肝炎诊断和治疗共识(2015)显示文摘一、概述自身免疫性肝炎(autoimmune hepatitis,AIH)是一种由针对肝细胞的自身免疫反应所介导的肝脏实质炎症,以血清自身抗体阳性、高免疫球蛋白G(Ig G)和(或)γ-球蛋白血症、肝组织学上存在界面性肝炎为特点,如不治疗常可导致肝硬化、肝功能衰竭~[1]。AIH的临床表现多样,一般表现为慢性、隐匿起病,但也可急性发作,甚至引起急性肝功能衰竭。上世纪60—80年代,多项临床研究证实, | 无 马雄 邱德凯 陈成伟 陈晓宇 成军 窦晓光 段钟平 范建高 傅青春 高春芳 韩英 侯金林 胡和平 胡锡琪 贾继东 刘玉兰 陆伦根 茅益民 苗琪 南月敏 任红 王贵强 王吉耀 王建设 王绮夏 王宇明 魏来 谢青 谢渭芬 许建明 闫惠平 杨长青 尤红 曾民德 张文宏 周新民 庄辉 诸葛宇征 邹晓平 | 2016 | 胃肠病学2016，21，3： | 82 |
| 2 | De novo autoimmune hepatitis in liver transplant: State-of-the-art review显示文摘In the two past decades, a number of communications, case-control studies, and retrospective reports have appeared in the literature with concerns about the development of a complex set of clinical, laboratory and histological characteristics of a liver graft dysfunction that is compatible with autoimmune hepatitis. The de novo prefix was added to distinguish this entity from a pre-transplant primary autoimmune hepatitis, but the globally accepted criteria for the diagnosis of autoimmune hepatitis have been adopted in the diagnostic algorithm. Indeed, de novo autoimmune hepatitis is characterized by the typical liver necroinflammation that is rich in plasma cells, the presence of interface hepatitis and the consequent laboratory findings of elevations in liver enzymes, increases in serum gamma globulin and the appearance of nonorgan specific auto-antibodies. Still, the overall features of de novo autoimmune hepatitis appear not to be attributable to a univocal patho-physiological pathway because they can develop in the patients who have undergone liver transplantation due to different etiologies. Specifically, in subjects with hepatitis C virus recurrence, an interferon-containing antiviral treatment has been indicated as a potential inception of immune system derangement. Herein, we attempt to review the currently available knowledge about de novo liver autoimmunity and its clinical management. | Ranka Vukotic Giovanni Vitale Antonia D'Errico-Grigioni Luigi Muratori Pietro Andreone | 2016 | World Journal of Gastroenterology2016，22，10： | 4 |
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