共被期刊论文引用了2次
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| 1 | Aberrant regulation of Wnt signaling in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most lethal malignancies in the world. Several signaling pathways,including the wingless/int-1(Wnt) signaling pathway,have been shown to be commonly activated in HCC. The Wnt signaling pathway can be triggered via both catenin β1(CTNNB1)-dependent(also known as 'canonical') and CTNNB1-independent(often referred to as 'non-canonical') pathways. Specifically,the canonical Wnt pathway is one of those most frequently reported in HCC. Aberrant regulation from three complexes(the cell-surface receptor complex,the cytoplasmic destruction complex and the nuclear CTNNB1/T-cell-specific transcription factor/lymphoid enhancer binding factor transcriptional complex) are all involved in HCC. Although the non-canonical Wnt pathway is rarely reported,two main non-canonical pathways,Wnt/planar cell polarity pathway and Wnt/Ca2+ pathway,participate in the regulation of hepatocarcinogenesis. Interestingly,the canonical Wnt pathway is antagonized by non-canonical Wnt signaling in HCC. Moreover,other signaling cascades have also been demonstrated to regulate the Wnt pathway through crosstalk in HCC pathogenesis. This review provides a perspective on the emerging evidence that the aberrant regulation of Wnt signaling is a critical mechanism for the development of HCC. Furthermore,crosstalk between different signaling pathways might be conducive to the development of novel molecular targets of HCC. | Li-Juan Liu Shui-Xiang Xie Ya-Tang Chen Jing-Ling Xue Chuan-Jie Zhang Fan Zhu | 2016 | World Journal of Gastroenterology2016，22，33： | 11 |
| 2 | IGF-IR与前列腺癌的研究进展显示文摘前列腺癌是男性每年肿瘤相关死亡的第二大致死因。数十年来,雄激素剥夺疗法是治疗晚期或转移性前列腺癌患者的黄金标准,但这种治疗策略仅获得最初的效益,最终进展为去势抵抗性前列腺癌,所有的治疗,仅仅相对延长生存期。胰岛素样生长因子1型受体(IGF-1R)的过度表达介导前列腺癌细胞的生存。阻断IGF-1R及其下游信号通路,具有抑制前列腺癌细胞增殖、分化及促凋亡的效应。本文就IGF-1R表达与前列腺癌的发生、进展及迁移的关系,以及靶向治疗IGF-1R信号通路的研究进展予以综述。 | 刘鹏 关超 | 2016 | 海南医学2016，27，10： | 7 |
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