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| 1 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 2 | 早产儿喂养不耐受的影响因素与治疗策略显示文摘目的了解早产儿喂养不耐受的影响因素,探讨有利于早产儿喂养成功的要点。方法收集2014年3月至2014年9月厦门市妇幼保健院新生儿科收治的发生喂养不耐受的早产儿进行回顾性分析。结果共收集到符合入选标准的早产儿病例374例,其中107例发生喂养不耐受,发生率为28.6%。出生体重≤1500 g的早产儿喂养不耐受发生率(71.23%)明显高于出生体重>1500 g的早产儿(18.27%),差异有显著性(P<0.01)。胎龄≤34周的早产儿喂养不耐受发生率(38.82%)高于>34周的早产儿(17.98%),差异有显著性(P<0.05)。>3天开奶的早产儿喂养不耐受发生率(40.59%)高于≤3天开奶的早产儿(18.63%),差异有显著性(P<0.01)。有窒息史的早产儿喂养不耐受发生率(44.76%)高于无窒息史早产儿(22.30%),差异有显著性(P<0.05)。有无呼吸暂停史与早产儿喂养不耐受的发生无相关性(P>0.05)。结论出生体重低、胎龄小、开奶延迟、有窒息史的早产儿易发生喂养不耐受。选择合适的乳类、合理选择开奶时间、早期给予微量喂养和非营养性吸吮、刺激排便、应用微生态制剂等治疗策略,可提高早产儿生存质量。 | 李雅丹 林新祝 黄静 李雅滨 | 2015 | 发育医学电子杂志2015，3，4： | 3 |
| 3 | Novel biomarkers of fibrosis in Crohn's disease显示文摘Fibrosis represents a major challenge in Crohn's disease(CD),and many CD patients will develop fibrotic strictures requiring treatment throughout their lifetime.There is no drug that can reverse intestinal fibrosis,and so endoscopic balloon dilatation and surgery are the only effective treatments.Since patients may need repeated treatments,it is important to obtain the diagnosis at an early stage before strictures become symptomatic with extensive fibrosis.Several markers of fibrosis have been proposed,but most need further validation.Biomarkers can be measured either in biological samples obtained from the serum or bowel of CD patients,or using imaging tools and tests.The ideal tool should be easily obtained,costeffective,and reliable.Even more challenging is fibrosis occurring in ulcerative colitis.Despite the important burden of intestinal fibrosis,including its detrimental effect on outcomes and quality of life in CD patients,it has received less attention than fibrosis occurring in other organs.A common mechanism that acts via a specific signaling pathway could underlie both intestinal fibrosis and cancer.A comprehensive overview of recently introduced biomarkers of fibrosis in CD is presented,along with a discussion of the controversial areas remaining in this field. | Gianluca Pellino Pierlorenzo Pallante Francesco Selvaggi | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，3： | 2 |
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