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		题名	作者	年代	出处	被引量
	1	Gingerol activates noxious cold ion channel TRPA1 in gastrointestinal tract显示文摘TRPA1 channels are non-selective cation channels that could be activated by plant-derived pungent products, including gingerol, a main active constituent of ginger. Ginger could improve the digestive function; however whether ginger improves the digestive function through activating TRPA1 receptor in gastrointestinal tract has not been investigated. In the present study, gingerol was used to stimulate cell lines(RIN14B or STC-1) while depletion of extracellular calcium.TRPA1 inhibitor(rethenium red) and TRPA1 gene silencing via TRPA1-specific si RNA were also used for mechanistic studies. The intracellular calcium and secretion of serotonin or cholecystokinin were measured by fura-2/AM and ELISA. Stimulation of those cells with gingerol increased intracellular calcium levels and the serotonin or cholecystokinin secretion. The gingerol-induced intracellular calcium increase and secretion(serotonin or cholecystokinin) release were completely blocked by ruthenium red, EGTA, and TRPA1-specific si RNA. In summary, our results suggested that gingerol derived from ginger might improve the digestive function through secretion releasing from endocrine cells of the gut by inducing TRPA1-mediated calcium influx.	YANG Meng-Qi YE Lin-Lan LIU Xiao-Ling QI Xiao-Ming LV Jia-Di WANG Gang FARHAN Ulah-Khan WAQAS Nawaz CHEN Ding-Ding HAN Lei ZHOU Xiao-Hui	2016	Chinese Journal of Natural Medicines2016，14，6：	6

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