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1Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease显示文摘Cranberry extract(CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid(Aβ) toxicity in C. elegans model of Alzheimer's disease(AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβtoxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβtoxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.GUO Hong DONG Yu-Qing YE Bo-Ping 2016Chinese Journal of Natural Medicines2016,14,6:2
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