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| 1 | Expression and significance of angiostatin, vascular endothelial growth factor and matrix metalloproteinase-9 in brain tissue of diabetic rats with ischemia reperfusion显示文摘Objective: To discuss the expression and significance of angiostatin, vascular endothelial growth factor and matrix metalloproteinase-9 in the brain tissue of diabetic rats with ischemia reperfusion. Methods: A total of 60 male Wistar rats were randomly divided into the normal group, sham group, diabetic cerebral infarction group and single cerebral infarction group according to the random number table, with 15 rats in each group. The high sucrose diet and intraperitoneal injection of streptozotocin were performed for the modeling of diabetic rats, while the thread-occlusion method was employed to build the model of cerebral ischemia reperfusion. The immunohistochemical staining was performed to detect the expression of angiostatin, vascular endothelial growth factor(VEGF) and matrix metalloproteinase-9(MMP-9) in the brain tissue. Results: The expression of angiostatin after the reperfusion in the brain tissue of rats in the single cerebral infarction group and diabetic cerebral infarction group was increased 6 h after the reperfusion, reached to the peak on 1 d and then decreased gradually. The expression of angiostatin in the diabetic cerebral infarction group 6 h, 1 d, 3 d and 7 d after the reperfusion was significantly higher than that in the single cerebral infarction group(P<0.05). VEGF began to be increased 1 h after the reperfusion in the single cerebral infarction group and diabetic cerebral infarction group, reached to the peak at 6 h and then decreased gradually. The expression of VEGF in the diabetic cerebral infarction group at each time point after the reperfusion was significantly lower than that in the single cerebral infarction group(P<0.05). MMP-9 began to be be increased 1 h after the reperfusion in the single cerebral infarction group and diabetic cerebral infarction group, reached to the peak on 1 d and then decreased gradually. The expression of MMP-9 in the diabetic cerebral infarction group at each time point after the reperfusion was significantly higher than that in the single cerebral infarction group(P<0.05). Conclusions: The high glucose environment in which the diabetic cerebral infarction is occurred is to induce the formation of MMP-9 at first and then activate and increase the expression of angiostatin. Afterwards, the expression of VEGF is inhibited, resulting in the poor angiogenesis after cerebral infarction, which thus makes the injury of brain tissue after cerebral infarction even worse than the non-diabetes mellitus. | Yu-Zhi Liang Zhi-Lei Zeng Lin-Lin Hua Jin-Feng Li Yun-Liang Wang Xi-Zhuang Bi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，6： | 9 |
| 2 | 胃腺癌术后组织中癌胚抗原相关黏附分子、基质金属蛋白酶-14表达特征及对血管生成的促进作用显示文摘目的检测胃腺癌术后组织中癌胚抗原相关黏附分子(CEACAM)6和基质金属蛋白酶(MMP)-14的表达,探讨其与血管内皮标志物白细胞分化抗原(CD)34阳性的微血管密度(MVD)的相关性。方法以胃腺癌术后组织85例作为观察组,选择77例距肿物边缘>3 cm的切端为正常的胃黏膜组织作为对照组,应用免疫组化方法检测CEACAM6、MMP-14和CD34的表达。结果观察组中CEACAM6、MMP-14的阳性率、MVD值均明显高于对照组。观察组中CEACAM6、MMP-14的阳性率、MVD值与最大径线、坏死、脉管浸润相关,MMP-14与淋巴结转移相关。线性相关分析显示CEACAM6和MVD、MMP-14和MVD呈正相关。结论胃腺癌中CEACAM6、MMP-14阳性率及MVD值均增高,不仅可以促进肿瘤的发生和进展,还可以在一定程度上判断肿瘤的生物学行为。CEACAM6、MMP-14可能与胃腺癌的血管生成有一定作用。 | 马金华 王丽娟 马金兰 马金祥 | 2015 | 中国老年学杂志2015，35，12： | 2 |
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