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| 1 | 半夏泻心汤及其苦降药组促进胃肠动力的PK-PD研究显示文摘目的探讨半夏泻心汤促进胃肠动力的物质基础、作用机制和配伍特点。方法将实验分为半夏泻心汤组及苦降药组,两组大鼠分别ig 给予两组药物水提醇沉液,于给药前(0 h)及给药后0.083、0.167、0.25、0.333、0.5、0.75、1、1.5、2、3、4、6、9、24 h 股静脉采血,ELISA 法测Cajal 间质细胞(ICC)中KIT 蛋白、Ca2+及ATP 酶的水平,同时采用液质联用(HPLC-MS)法检测血清中黄芩苷、黄芩素、小檗碱、巴马汀的浓度,采用Winnonlin 软件进行药动学(PK)- 药效学(PD)结合模型合。结果半夏泻心汤及其苦降药组均能下调 ICC 中Ca2+浓度及上调ICC 中ATP 酶的水平;且对ICC 内KIT 蛋白水平无显著影响。半夏泻心汤及其苦降药组降低Ca2+浓度的效应中巴马汀以有滞后时间三房室-Sigmoid ImaxPK-PD模型连接,小檗碱、黄芩素以有滞后时间二房室-Sigmoid Imax PK-PD 模型连接。半夏泻心汤及其苦降药组上调ATP 酶的效应中巴马汀以有滞后时间三房室-Sigmoid Emax PK-PD 模型连接,小檗碱、黄芩素以有滞后时间二房室-Sigmoid Emax PK-PD模型连接。结论半夏泻心汤及其苦降药组促进胃肠动力的作用可能与其降低ICC 内Ca2+浓度、上调细胞ATP 酶水平有关。ICC 内Ca2+浓度的降低、ATP 酶水平的上调可能与半夏泻心汤及其苦降药组中巴马汀、小檗碱、黄芩素有关。半夏泻心汤在PK 和PD 方面均优于苦降药组,体现出全方的配伍优势。 | 罗太敏 李晋奇 杨戈 张德 童荣生 | 2015 | 药物评价研究2015，38，6： | 22 |
| 2 | Effects of Lizhong Tang on gastrointestinal motility in mice显示文摘AIM To investigate the effects of Lizhong Tang,a traditional Chinese medicine formula,on gastrointestinal motility in mice.METHODS The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates(ITRs) and gastric emptying(GE) values in normal mice and in mice with experimentally induced GI motility dysfunction(GMD).RESULTS In normal ICR mice,the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang(ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%,P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%,P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%,P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%,P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice,which were significantly and dose-dependently reversed by Lizhong Tang. Additionally,in loperamide- and cisplatin-induced models of GE delay,Lizhong Tang administration reversed the GE deficits.CONCLUSION These results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract. | Min Cheol Lee Wooram Ha Jinhyeong Park Junghoon Kim Yunjin Jung Byung Joo Kim | 2016 | World Journal of Gastroenterology2016，22，34： | 4 |
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