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| 1 | 自体血回输对高龄骨科患者围术期血液氧合的影响显示文摘目的探讨自体血回输对高龄骨科手术患者围术期血液氧合的影响。方法选择骨科手术高龄患者40例,随机分为自体血回输组和对照组,每组20例,回输组术中应用自体血液回收机进行血液收集、回输,对照组输注同种异体血。观察2组患者分别于手术前(T1)、手术结束时(T2)、术后24 h(T3)抽取颈内静脉,桡动脉血,记录动脉血氧分压(PaO_2)、混合静脉血氧分压(PvO_2)、动脉血氧饱和度(SaO_2)、混合静脉血氧饱和度(SvO_2)、动脉血氧含量(CaO_2)、静脉血氧含量(CvO_2)以及氧摄取率(ERO_2);观察术中失血量、补液量、输血量,尿量及输血并发症情况。结果回输组输注异体浓缩红细胞量及血浆用量与对照组比较,差异有统计学意义(P<0.05)。手术结束时,回输组PaO_2、PvO_2、SvO_2、CaO_2、CvO_2均高于对照组,差异有统计学意义(P<0.05);与对照组比较,回输组ERO_2降低(P<0.05)。结论自体血回输可显著减少老年骨科手术异体血输入,改善氧合,增加氧供,可安全用于高龄骨科手术患者。 | 赵爽 王秀丽 刘飞飞 段卫东 吴川 仝烨峰 | 2016 | 河北医药2016，38，18： | 6 |
| 2 | Effect of HDAC-6 on PD cell induced by lactacystin显示文摘Objective:To explore the effects of histone deacetylase 6(HDAC-6) on the PD cell model induced by proteasome inhibitor lactacystin.Methods:Human neuroblastoma SK-N-SH cells were cultured.The wild type pcDNA3.1-alpha-synuclein eukaryotic expression plasmid was transferred into the cells which then were divided into control group,group L,group T and group T+L.The eells of group L were added with 5 umol/L lactacystin dissolved in dimethylsulfoxide(DMSO) to induce PD cell model with abnormal protein aggregation,the cells of control group were treated with 5 umol/L DMSO,the cells of group T were treated with 5 umol/L selective HDAC-6 inhibitor tubacin dissolved in DMSO,and the cells of group T+L were treated with 5 umol/L lactaeystin and 10 umol/L tubacin dissolved in DMSO.The expression levels of alpha-synuclein oligomers,HSP-27 and HSP-70 were detected by Western blot and the cell survival rate of all the groups was detected by MTT colorimetric assay,and compared 24 h after the cells were treated.Results:The expression levels of alpha-synuclein oligomers,HSP-27 and HSP-70 of the cells of group L were significantly higher than the control group,and the cell survival rate was significantly lower(P<0.05);the expression level of alpha-synuclein oligomers of the cells of group T+L was significantly higher than group L,but the expression level of HSP-27 and HSP-70 were significantly lower,and so as the cell survival rate(P<0.05);the differences of the expression level of alpha-synuclein oligomers,HSP-27 and HSP-70 and the cell survival rate of the cells of group T and the control group were not statistically significant(P>0.05).Conclusions:The expression level of alphasynuclein oligomers can be improved and the cell survival rate can be reduced by the PD cell model induced by lactacystin and treated with selective HDAC-6 inhibitor tubacin,which means that alpha-synuclein oligomers of the PD cell model induced by lactacystin can be inhibited and the cell survival rate can be improved by HDAC-6,and the mechanism may be related to the increased of HSP-27 and HSP-70. | Li-Fei Xing Dong-Tao Wang Yu Yang Su-Yue Pan | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，10： | 0 |
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