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    题名 作者 年代 出处 被引量
1益肾填精颗粒对慢性脑供血不足患者认知功能的影响显示文摘目的观察益肾填精法治疗慢性脑供血不足(CCCI)的疗效。方法 30例CCCI患者,均在维持其原有西医治疗(降压药、降糖药、降脂药等)基础上予口服自拟'益肾填精颗粒'3个月。观察30例患者治疗后临床疗效及入组当天和3个月简易精神状态检查量表(MMSE)、蒙特利尔认知评测量表(Mo CA)、慢性脑供血不足症状量表评分变化情况。结果 30例患者治疗后总有效率为90%,治疗前后MMSE、Mo CA及慢性脑供血不足症状量表评分比较差异有统计学意义(P<0.05)。结论益肾填精法可改善慢性脑供血不足患者认知功能及其他症状。张娜 陈志刚 唐媛 李楠楠 2016世界中西医结合杂志2016,11,1:3
2Effects of Gastrodiae rhizoma on proliferation and differentiation of human embryonic neural stem cells显示文摘Objective:To investigate the effects of Gastrodiae rhizoma,a dried root of Gastrodia elata Blume,on proliferation and differentiation of human NSCs derived from embryonic stem cells.Methods:A 70%ethanol extract of Gastrodiae rhizoma(EEGR) was estimated with4-hydroxybenzyl alcohol as a representative constituent by HPLC.Results:MTT assay showed that the treatment with EEGR increased the viability of NSCs in growth media.Compared to contro1,EEGR increased the number of dendrites and denritic spines extended from a differentiated NSC.Whereas EEGR decreased the mRNA expression of Nestin,it increased that of Tuj1 and MAP2 in NSCs grown in differentiation media.Immunocytochemical analysis using confocal microscopy also revealed the increased expression of MAP2 in dendrites of EEGR-treated NSCs.Furthermore,EEGR decreased mRNA expression of Sox2 in NSCs grown even in growth media.Conclusions:In conclusion,our study demonstrates for the first time that EEGR induced proliferation and neuronal differentiation of NSCs,suggesting its potential benefits on NSC-based therapies and neuroregeneration in various neurodegenerative diseases and brain Injuries.Samrat Baral Ramesh Pariyar Chi-Su Yoon Dong-Cheol Kim Jong-Min Yun Seok O Jang Sung Yeon Kim Hyuncheol Oh Youn-Chul Kim Jungwon Seo 2015Asian Pacific Journal of Tropical Medicine2015,8,10:2
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