| 1 | Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients,in-vitro and invivo reproducibility显示文摘There is considerable disparity in the published apparent diffusion coefficient(ADC) values across different anatomies. Institutions are increasingly assessing repeatability and reproducibility of the derived ADC to determine its variation,which could potentially be used as an indicator in determining tumour aggressiveness or assessing tumour response. In this manuscript,a review of selected articles published to date in healthy extracranial body diffusion-weighted magnetic resonance imaging is presented,detailing reported ADC values and discussing their variation across different studies. In total 115 studies were selected including 28 for liver parenchyma,15 for kidney(renal parenchyma),14 for spleen,13 for pancreatic body,6 for gallbladder,13 for prostate,13 for uterus(endometrium,myometrium,cervix) and 13 for fibroglandular breast tissue. Median ADC values in selected studies were found to be 1.28 × 10-3 mm2/s in liver,1.94 × 10-3 mm2/s in kidney,1.60 × 10-3 mm2/s in pancreatic body,0.85 × 10-3 mm2/s in spleen,2.73 × 10-3 mm2/s in gallbladder,1.64 × 10-3 mm2/s and 1.31 × 10-3 mm2/s in prostate peripheral zone and central gland respectively(combined median value of 1.54×10-3 mm2/s),1.44 × 10-3 mm2/s in endometrium,1.53 × 10-3 mm2/s in myometrium,1.71 × 10-3 mm2/s in cervix and 1.92 × 10-3 mm2/s in breast. In addition,six phantom studies and thirteen in vivo studies were summarized to compare repeatability and reproducibility of the measured ADC. All selected phantom studies demonstrated lower intra-scanner and inter-scanner variation compared to in vivo studies. Based on the findings of this manuscript,it is recommended that protocols need to be optimised for the body part studied and that system-induced variability must be established using a standardized phantom in any clinical study. Reproducibility of the measured ADC must also be assessed in a volunteer population,as variations are far more significant in vivo compared with phantom studies. | Maysam M Jafar Arman Parsai Marc E Miquel | 2016 | World Journal of Radiology2016，8，1： | 2 |
| 2 | 多体素~1H-MRS分析单一胶质瘤不同区域的增殖性差异显示文摘目的探讨多体素氢质子磁共振波谱分析(1H-MRS)所示代谢物比值显著差异区域与肿瘤组织增殖活性的相关性研究及其应用价值方法 2011年12月-2013年8月宁夏医科大学总医院收治胶质瘤患者30例,术前3.0T多体素1H-MRS选取代谢明显差异的兴趣区,即Cho/Cr高代谢区、Cho/Cr低代谢区,神经导航辅助下穿刺,获取的组织行免疫组化观察其ki-67表达水平。结果 MRI显示恶性程度低的胶质瘤T1像呈低信号,T2像高信号,信号较均匀,边界清楚。恶性程度高的胶质瘤呈长T1、长T2信号,信号不均匀或呈混杂信号。肿瘤的恶性程度越高,NAA/Cho、NAA/Cr的比值下降越明显(P<0.05),多体素1H-MRS显示单一瘤体不同区域体素之间,代谢物Cho/Cr比值差异有统计学意义(P<0.05);Cho/Cr高代谢区ki-67表达量为(59.50±17.23)%高于Cho/Cr低代谢区ki-67表达量(5.73±3.40)%(P<0.05),相关性分析显示,Cho/Cr比值与ki-67表达量具有正相关性(r=0.874,P<0.01)。结论多体素1H-MRS能有效反映单一瘤体不同区域的增殖活性差异,能有效寻找到瘤体增殖代谢旺盛区域,为指导临床手术提供一定的理论依据。 | 王喜隆 田秋思 夏鹤春 马辉 张涛 | 2015 | 宁夏医科大学学报2015，37，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员