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| 1 | From the stomach to other organs:Helicobacter pylori and the liver显示文摘Many recent studies have examined the importance of Helicobacter pylori(H. pylori) infection in the pathogenesis of the diseases outside the stomach and explored the significance of this bacterium in the pathogenesis of some metabolic and cardiovascular diseases. Recent studies have provided evidence that H. pylori is also involved in the pathogenesis of some liver diseases. Many observations have proved that H. pylori infection is important in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, liver fibrosis and cirrhosis. The worsening of liver inflammation of different origins also occurs during H. pylori infection. Some studies have indicated that H. pylori infection induces autoimmunological diseases in the liver and biliary tract. The potential significance of this bacterium in carcinogenesis is unclear, but it is within the scope of interest of many studies. The proposed mechanisms through which H. pylori impacts the development of hepatobiliary diseases are complex and ambiguous. The importance of other Helicobacter species in the development of hepatobiliary diseases is also considered because they could lead to the development of inflammatory, fibrotic and necrotic injuries of the liver and, consequently, to hepatocellular carcinoma. However, many contrary viewpoints indicate that some evidence is not convincing, and further studies of the subject are needed. This review presents the current knowledge about the importance of H. pylori in the pathogenesis of liver and in biliary diseases. | Marek Waluga Michal Kukla Michal Zorniak Agata Bacik Rafal Kotulski | 2015 | World Journal of Hepatology2015，7，18： | 11 |
| 2 | 10kDa以上幽门螺杆菌感染相关尿液差异表达蛋白的高效液相色谱-质谱分析显示文摘背景:除消化性溃疡和胃癌外,幽门螺杆菌(Hp)感染尚与多种胃肠外疾病密切相关。目前临床上尚无Hp感染的体液检测方法。目的:鉴定相对分子质量在10 k Da以上的Hp感染相关尿液差异表达蛋白,为Hp感染的体液诊断提供潜在生物学标记物。方法:志愿者留取晨起中段尿,并行13C-尿素呼气试验以明确Hp感染情况。Hp阴性和阳性尿液样本各取15例,分别混合后提取蛋白,以高效液相色谱-质谱系统分离蛋白、采集数据,行label-free定量分析。另取Hp阴性尿液样本15例和阳性尿液样本11例,对差异表达分析结果进行全扫描验证。应用IPA软件对鉴定出的尿液差异表达蛋白进行生物信息学分析。结果:Label-free定量分析共检测到475个尿液蛋白,并确定其中42个为差异表达蛋白。经外部扫描验证,最终鉴定出11个显著上调的差异表达蛋白。生物信息学分析揭示了这些差异表达蛋白的分子功能、参与的生物学通路、相关疾病等信息。结论:鉴定出的11个10 k Da以上尿液差异表达蛋白有望成为诊断Hp感染的生物学标记物,并可为Hp感染与胃肠外疾病的相关性研究提供分子水平的证据。 | 张慧芳 孟凡亮 何利华 张建中 肖迪 | 2016 | 胃肠病学2016，21，3： | 2 |
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