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| 1 | Watch and wait approach to rectal cancer: A review显示文摘In 2014, there were an estimated 136800 new cases of colorectal cancer, making it the most common gastrointestinal malignancy. It is the second leadingcause of cancer death in both men and women in the United States and over one-third of newly diagnosed patients have stage Ⅲ(node-positive) disease. For stage Ⅱ and Ⅲ colorectal cancer patients, the mainstay of curative therapy is neoadjuvant therapy, followed by radical surgical resection of the rectum. However, the consequences of a proctectomy, either by low anterior resection or abdominoperineal resection, can lead to very extensive comorbidities, such as the need for a permanent colostomy, fecal incontinence, sexual and urinary dysfunction, and even mortality. Recently, trends of complete regression of the rectal cancer after neoadjuvant chemoradiation therapy have been confirmed by clinical and radiographic evaluationthis is known as complete clinical response(cC R). The 'watch and wait' approach was first proposed by Dr. Angelita Habr-Gama in Brazil in 2009. Those patients with c CR are followed with close surveillance physical examinations, endoscopy, and imaging. Here, we review management of rectal cancer, the development of the 'watch and wait' approach and its outcomes. | Marcos E Pozo Sandy H Fang | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 2 |
| 2 | 低位直肠癌新辅助放化疗后Watchful Waiting治疗策略的应用显示文摘直肠癌是世界范围内的常见肿瘤,直肠癌新辅助放化疗后患者症状缓解,证实为临床完全缓解的患者给予观察随访,被认为可以代替外科手术治疗。针对新辅助放化疗后应用'Watchful Waiting'治疗策略的相关问题做一综述。 | 寇智勇 李文亮 | 2015 | 世界最新医学信息文摘2015，15，84： | 0 |
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