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		题名	作者	年代	出处	被引量
	1	RNA干扰K-ras基因对肺腺癌H441细胞EGFR-TKI耐药性的影响显示文摘目的探讨RNA干扰K-ras基因对肺腺癌H441细胞株细胞EGFR-TKI耐药性的影响。方法构建靶向K-ras基因的表达载体并转染肺腺癌H441细胞,分别检测转染后细胞中K-ras蛋白及基因表达以及对吉非替尼敏感性的改变。结果实验组中K-ras基因及蛋白的表达量明显低于对照组(P<0.05);实验组中细胞凋亡率及细胞增殖抑制率均显著升高(P<0.05)。结论靶向突变K-ras基因的si RNA可以诱导肺腺癌H441细胞凋亡,减弱对吉非替尼的耐药性,为肺癌的基因治疗提供了新的思路和方法。	胡述提金冰林涛	2015	中国老年学杂志2015，35，11：	4
	2	Genomic alterations in pancreatic cancer and their relevance to therapy显示文摘Pancreatic cancer is a highly lethal cancer type, for which there are few viable therapeutic options. But, with the advance of sequencing technologies for global genomic analysis, the landscape of genomic alterations in pancreatic cancer is becoming increasingly well understood. In this review, we summarize current knowledge of genomic alterations in 12 core signaling pathways or cellular processes in pancreatic ductal adenocarcinoma, which is the most common type of malignancy in the pancreas, including four commonly mutated genes and many other genes that are mutated at low frequencies. We also describe the potential implications of these genomic alterations for development of novel therapeutic approaches in the context of personalized medicine.	Erina Takai Shinichi Yachida	2015	World Journal of Gastrointestinal Oncology2015，7，10：	2

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