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| 1 | PI3K/AKT信号通路与结肠癌细胞5-氟尿嘧啶耐药机制的关系显示文摘化疗药物耐药是影响肿瘤有效治疗的主要因素之一。5-氟尿嘧啶(5-fluorouracil,5-FU)作为一种基础化疗药物,其耐药机制成为研究热点。磷脂酰肌醇-3-激酶/蛋白激酶B(phosphatidylinositol-3-kinase/protein kinase B,PI3K/AKT)信号转导通路在促进细胞生长、运动、增殖、侵袭,抑制细胞凋亡,促进血管生成,抵抗化疗和放疗等方面起重要作用。近年来,关于PI3K/AKT信号通路与药物耐药性关系的研究越来越多,并被认为是化疗耐药治疗的新靶点。笔者查阅国内外近年来有关PI3K/AKT信号通路在结肠癌细胞5-FU耐药中作用机制的文献并做综述。 | 温彦斐 王俊 毕经旺 | 2015 | 中国肿瘤生物治疗杂志2015，22，6： | 6 |
| 2 | Role of retinoids in the prevention and treatment of colorectal cancer显示文摘Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer chemotherapeutic agents. With respect to colorectal cancer(CRC), several critical mutations dysregulate pathways implicated in progression and metastasis, resulting in aberrant Wnt/β-catenin signaling, gain-of-function mutations in K-ras and phosphatidylinositol-3-kinase/Akt, cyclooxygenase-2 over-expression, reduction of peroxisome proliferatoractivated receptor γ activation, and loss of p53 function. Dysregulation leads to increased cellular proliferation and invasion and decreased cell-cell interaction and differentiation. Retinoids affect these pathways by various mechanisms, many involving retinoic acid receptors(RAR). RAR bind to all-trans-retinoic acid(ATRA) to induce the transcription of genes responsible for cellular differentiation. Although most research concerning the chemotherapeutic efficacy of retinoids focuses on the ability of ATRA to decrease cancer cell proliferation, increase differentiation, or promote apoptosis; as CRC progresses, RAR expression is often lost, rendering treatment of CRCs with ATRA ineffective. Our laboratory focuses on the ability of dietary vitamin A to decrease CRC cell proliferation and invasion via RAR-independent pathways. This review discusses our research and others concerning the ability of retinoids to ameliorate the defective signaling pathways listed above and decrease tumor cell proliferation and invasion through both RAR-dependent and RAR-independent mechanisms. | Catherine C Applegate Michelle A Lane | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 2 |
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