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| 1 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 2 | 组织多普勒成像测量E/Ea评价胸部放疗对患者左心室功能影响的价值显示文摘目的探讨组织多普勒成像(TDI)技术测量二尖瓣舒张早期左室充盈峰值流速(E)/舒张早期运动速度峰值(Ea)评价胸部放疗对患者左心室功能影响的临床价值。方法将80例患者依据是否联合化疗分为单纯放疗组(A组)、放疗联合化疗组(B组)各40例,分别于放疗前后采用TDI测定E、心房收缩期左室充盈峰值流速(A)、二尖瓣环收缩期运动速度峰值(Sa)、Ea、心房收缩期运动速度峰值(Aa),计算E/A、E/Ea值。结果 A组放疗前后E、A、E/A、Sa比较差异无统计学意义(P均>0.05),Ea减低(P<0.05),Aa、E/Ea升高(P均<0.05);B组放疗前后E、A、E/A比较差异无统计学意义(P均>0.05),Ea、Sa减低(P均<0.05),Aa、E/Ea升高(P均<0.05);放疗后B组与A组比较,Ea、Sa降低,Aa、E/Ea升高(P均<0.05)。结论 TDI测量的E/Ea可作为评价胸部放疗患者左心室功能早期损害的敏感指标。 | 姚世发 江翠华 汤燕芳 周宁明 | 2015 | 山东医药2015，55，41： | 7 |
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