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| 1 | Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum显示文摘Colorectal cancer(CRC) is the third most common cancer and the fourth most common cause of cancerrelated death worldwide. Besides the lymphatic and haematogenous routes of dissemination,CRC frequently gives rise to transcoelomic spread of tumor cells in the peritoneal cavity,which ultimately leads to peritoneal carcinomatosis(PC). PC is associated with a poor prognosis and bad quality of life for these patients in their terminal stages of disease. A loco-regional treatment modality for PC combining cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy has resulted in promising clinical results. However,this novel approach is associated with significant morbidity and mortality. A comprehensive understanding of the molecular events involved in peritoneal disease spread is paramount in avoiding unnecessary toxicity. The emergence of PC is the result of a molecular crosstalk between cancer cells and host elements,involving several well-defined steps,together known as the peritoneal metastatic cascade. Individual or clumps of tumor cells detach from the primary tumor,gain access to the peritoneal cavity and become susceptible to the regular peritoneal transport. They attach to the distant peritoneum,subsequently invade the subperitoneal space,where angiogenesis sustains proliferation and enables further metastatic growth. These molecular events are not isolated events but rather a continuous and interdependent process. In this manuscript,we review current data regarding the molecular mechanisms underlying the development of colorectal PC,with a special focus on the peritoneum and the role of the surgeon in peritoneal disease spread. | Lieselotte Lemoine Paul Sugarbaker Kurt Van der Speeten | 2016 | World Journal of Gastroenterology2016，22，34： | 12 |
| 2 | 抗肿瘤药LS-177的药物动力学研究显示文摘目的建立一种超高效液相色谱-串联质谱法(UPLC-MS/MS),测定新药LS-177比格犬血浆质量浓度,并将此方法用于测定LS-177的口服生物利用度,为LS-177口服制剂的研究提供科学数据。方法利用双周期交叉实验方案,以比格犬为试验对象,选用液-液萃取的血浆处理方法,利用UPLC-MS/MS法对比格犬血样进行测定。结果 LS-177的血浆质量浓度分别在0.1~400和2~2 000μg·L-1内呈线性,方法精密度(RSD)和准确度(RE)分别小于10.38%和14.71%,LS-177的口服生物利用度为10.05%。结论建立的UPLC-MS/MS法可用于LS-177的药物动力学研究,LS-177口服生物利用度低。 | 张健 郑琪 魏思佳 唐星 王艳娇 | 2015 | 中国药剂学杂志(网络版)2015，13，5： | 0 |
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