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| 1 | 生物支架材料治疗肛瘘的研究进展显示文摘近年来,随着分子生物学、细胞生物学和生物组织工程学等技术的发展,生物支架材料作为一种新兴技术渐渐在临床外科等各个领域获得普遍应用。目前很多学者经过实验研究证明了使用生物支架材料制作成的肛瘘栓(Anal Fistula Plug,AFP)在临床上有着广大应用价值。笔者通过查阅国内外生物支架材料在治疗肛瘘方面的相关文献,对人工合成材料、天然生物衍生材料以及复合材料的应用与研究做一综述,并展望了其未来的发展方向。 | 谢宏 禹正杨 | 2015 | 大家健康(学术版)2015，，5： | 3 |
| 2 | Prospective evaluation of a new device for the treatment of anal fistulas显示文摘AIM: To evaluate the safety of the implantation of a new device for the treatment of anal fistulas. The short-term clinical efficacy was also assessed. METHODS: This study took place at a tertiary care university hospital. Patients with a complex anal fistula of cryptoglandular origin were enrolled in the study and were treated with insertion of the new device. All patients were evaluated by clinical and physical examination, including an endoanal ultrasound at the baseline, and then at the 2 wk and 1, 2, 3 and 6-mo follow-up visits. RESULTS: Morbidity, continence status, and success rate were the main outcome measures. Ten patients underwent the placement of the new device. The fistulas were transphincteric in eight patients and extrasphincteric in the remaining two. The median duration of the surgical procedure was 34.5(range, 27-42) min. Neither intra- nor postoperative complications occurred, and all patients were discharged the day after the procedure. At the 6-mo follow-up evaluation, the final success rate was 70%. Three failures were registered: a device expulsion(on the 10 th postoperative day), the persistence of inflammatory tissue around the fistula tract(at the 2-mo follow up), and the persistence of serum discharge(at the 6-mo follow up). No patient experienced any change incontinence, as assessed by the Cleveland Clinic Fecal Incontinence score. CONCLUSION: The technical procedure is simple and has low risk of perioperative morbidity. The pre- and post-operative continence status did not change in any of the patients. The initial results at the 6-mo follow up seem to be promising. However, a longer follow-up period and a larger sample size are needed to confirm these preliminary results. | Carlo Ratto Francesco Litta Lorenza Donisi Angelo Parello | 2016 | World Journal of Gastroenterology2016，22，30： | 2 |
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