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1Recent advances in mass spectrometry-based proteomics of gastric cancer显示文摘The last decade has witnessed remarkable technological advances in mass spectrometry-based proteomics. The development of proteomics techniques has enabled the reliable analysis of complex proteomes, leading to the identification and quantification of thousands of proteins in gastric cancer cells, tissues, and sera. This quantitative information has been used to profile the anomalies in gastric cancer and provide insights into the pathogenic mechanism of the disease. In this review, we mainly focus on the advances in mass spectrometry and quantitative proteomics that were achieved in the last five years and how these up-andcoming technologies are employed to track biochemical changes in gastric cancer cells. We conclude by presenting a perspective on quantitative proteomics and its future applications in the clinic and translational gastric cancer research.Changwon Kang Yejin Lee J Eugene Lee 2016World Journal of Gastroenterology2016,22,37:8
2肝脏蛋白质组学的方法学研究进展显示文摘'蛋白质组(proteome)'指的是由1个基因组表达的全部蛋白质,1994年Marc Wilkins在意大利Siena会议上提出了这一概念。蛋白质组学(proteomics)是指应用各种技术手段来研究蛋白质组的学科,其目的是从整体的角度研究生物机体、组织、细胞甚至细胞器基因编码的全部蛋白质,包括蛋白的组成、分布、种类、功能、代谢特征及其动态变化规律等[1]。肝脏是身体内以代谢功能为主的器官,起着去氧化、樊昊 丁文 徐琰 2015河南医学研究2015,24,10:0
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