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| 1 | Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection显示文摘AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis. | HMC Shantha Kumara David Gaita Hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth Linda Njoh Vesna Cekic Richard L Whelan | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 4 |
| 2 | YKL-40在结核性胸腔积液中的临床价值显示文摘目的 :评估YKL-40在结核性胸腔积液(TBPEs)中的临床价值。方法 :采用前瞻性的研究方法,选取2009年1月1日~2013年12月31日在我科住院治疗的85例胸腔积液患者,其中TBPEs组68例,充血性心力衰竭性胸腔积液(CHFPEs)组17例,测定比较胸腔积液中YKL-40(YKL-40pl)浓度和血清中YKL-40(YKL-40se)浓度。应用受试者工作特征曲线(ROC曲线)分析YKL-40pl浓度诊断TBPEs的敏感性和特异性。结果 :TBPEs组患者YKL-40pl浓度明显高于CHFPEs组(269.8±23.4ng/m L vs.202.3±25.1 ng/m L);TBPEs组患者YKL-40se浓度低于CHFPEs组(59.5±12.4ng/m L vs 185.9±14.4 ng/m L)。ROC曲线分析:17例CHFPEs组患者为对照组做ROC曲线分析,当YKL-40pl浓度≥244.5 ng/m L时,诊断TBPEs的敏感性为85.4%、特异性为73.2%,曲线下面积(AUC)=0.935,95%可信区间(CI)为0.878-0.992;当YKL-40pl/YKL-40se≥1.8时,诊断TBPEs的敏感性89.2%,特异性96.4%,AUC=0.958,95%CI为0.936-0.996。结论 :TBPEs组患者YKL-40pl浓度明显高于CHFPEs组;TBPEs组患者YKL-40se浓度低于CHFPEs组;YKL-40pl浓度/YKL-40se浓度≥1.8时,可能有助诊断结核性胸腔积液。 | 李建民 刘志光 龙小平 关晶 | 2015 | 湖南师范大学学报(医学版)2015，12，3： | 2 |
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