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| 1 | Genetics of coronary artery disease and myocardial infarction显示文摘Atherosclerotic coronary artery disease(CAD) comprises a broad spectrum of clinical entities that include asymptomatic subclinical atherosclerosis and its clinical complications, such as angina pectoris, myocardial infarction(MI) and sudden cardiac death. CAD continues to be the leading cause of death in industrialized society. The long-recognized familial clustering of CAD suggests that genetics plays a central role in its development, with the heritability of CAD and MI estimated at approximately 50% to 60%. Understanding the genetic architecture of CAD and MI has proven to be difficult and costly due to the heterogeneity of clinical CAD and the underlying multi-decade complex pathophysiological processes that involve both genetic and environmental interactions. This review describes the clinical heterogeneity of CAD and MI to clarify the disease spectrum in genetic studies, provides a brief overview of the historical understanding and estimation of the heritability of CAD and MI, recounts major gene discoveries of potential causal mutations in familial CAD and MI, summarizes CAD and MIassociated genetic variants identified using candidate gene approaches and genome-wide association studies(GWAS), and summarizes the current status of the construction and validations of genetic risk scores for lifetime risk prediction and guidance for preventive strategies. Potential protective genetic factors against the development of CAD and MI are also discussed. Finally, GWAS have identified multiple genetic factors associated with an increased risk of in-stent restenosis following stent placement for obstructive CAD. This review will also address genetic factors associated with in-stent restenosis, which may ultimately guide clinical decision-making regarding revascularization strategies for patients with CAD and MI. | Xuming Dai Szymon Wiernek James P Evans Marschall S Runge | 2016 | World Journal of Cardiology2016，8，1： | 15 |
| 2 | 冠心病患者血清对氧磷酶-1水平变化及其临床意义显示文摘目的:探讨冠心病(CHD)患者血清对氧磷酶-1(PON1)水平变化及其临床意义。方法:采用ELISA法检测80例CHD患者和50例非CHD患者(对照组)的血清PON1水平,同时检测两组患者的血脂各项指标。结果:CHD组的血清PON1水平明显低于对照组,差异有统计学意义,P<0.01;CHD组的血清PON1水平与与HDL-C呈显著正相关(γ=0.403,P<0.01),与ox-LDL(γ=-0.648,P<0.01)呈显著负相关,但与其余血脂各项指标相关性无统计学意义。CHD组治疗后的血清PON1水平明显高于治疗前,差异有统计学意义,P<0.01。结论:冠心病患者血清PON1水平明显降低,监测其水平有助于冠心病的诊断和疗效评估。 | 夏真珍 | 2013 | 大家健康(学术版)2013，，21： | 1 |
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