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| 1 | Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease显示文摘The search for biomarkers that characterize specific aspects of inflammatory bowel disease(IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility(or expectancy to be reproducible and translationable into humans) or already measured in humans. A few testshave shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients. | Emilio G Quetglas Zlatan Mujagic Simone Wigge Daniel Keszthelyi Sebastian Wachten Ad Masclee Walter Reinisch | 2015 | World Journal of Gastroenterology2015，21，44： | 3 |
| 2 | 巨噬细胞免疫效应与溃疡性结肠炎的研究进展显示文摘巨噬细胞在机体免疫反应的调节中起重要作用,不同组织微环境能影响其表型和功能,以调控不同免疫效应。研究发现巨噬细胞功能异常与溃疡性结肠炎(UC)的发生、发展间存在高度相关性,靶向调节巨噬细胞的免疫活性能有效改善UC患者的临床症状和肠道组织学病变。通过改善微环境以调节巨噬细胞的活化、迁移可能是艾灸治疗UC的起效机制之一。本文就巨噬细胞免疫效应与UC的研究进展作一综述。 | 张丹 华雪桂 刘婕 丰晓溟 钱晨 魏凯 翁志军 吴焕淦 马晓芃 | 2014 | 胃肠病学2014，19，8： | 2 |
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