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| 1 | Helicobacter pylori and functional dyspepsia: An unsolved issue?显示文摘Patients with Helicobacter pylori(H. pylori) infection may complain of dyspeptic symptoms without presence of macroscopic lesions on gastroduodenal mucosa. Such a condition is usually recognized as functional dyspepsia, and different pathogenetic mechanisms are involved. The role of H. pylori in these patients is controversial. Several trials assessed the potential role of H. pylori eradication in improving dyspeptic symptoms, and data of some meta-analyses demonstrated that cure of infection is associated with a small(10%), but significant therapeutic gain as compared to placebo. The reason for which dyspeptic symptoms regress in some patients following bacterial eradication, but persist in others remains unclear. Regrettably, trials included in the meta-analyses are somewhat different for study design, definition of symptoms, assessment of symptoms changes, and some may be flawed by potential pitfalls. Consequently, the information could be not consistent. We critically reviewed the main available trials, attempting to address future research in this | Angelo Zullo Cesare Hassan Vincenzo De Francesco Alessro Repici Raffaele Manta Silverio Tomao Bruno Annibale Dino Vaira | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Dysbiotic infection in the stomach显示文摘Microbiota in human alimentary tract plays important roles for homeostatic maintenance of the body. Compositional difference of gut microbiota is tightly associated with susceptibility of many diseases,including inflammatory diseases,obesity,diabetes mellitus,cancer,and atherosclerosis. 'Dysbiosis' refers to a state of imbalance among the colonies of microorganisms within the body,which brings abnormal increase of specific minor components and decrease in the normally dominant species. Since stomach secrets strong acid for its digestive role,this organ has long been thought a sterile organ. However,the discovery of Helicobacter pylori(H. pylori) has changed the concept. This bacterium has proven to cause gastritis,peptic ulcer,and gastric cancer. However,recent cross-sectional studies revealed that H. pylori carriers had a decreased risk of developing immunological diseases,such as asthma. H. pylori coinfection also suppresses inflammatory bowel diseases. This review describes human gastric microbiota by discussing its mutual interaction and pathogenic enrollment. Gastric 'dysbiosis' may affect host inflammatory response and play important role for gastric pathogenesis. We will topically discuss enrollment of dysbiosis for genesis of gastric cancer as well as for disruption of immunological homeostasis affecting oncogenic resistance. | Hisashi Iizasa Shyunji Ishihara Timmy Richardo Yuichi Kanehiro Hironori Yoshiyama | 2015 | World Journal of Gastroenterology2015，21，40： | 5 |
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