| 1 | Relationship between excessive erythrocytosis and acute mountain sickness: A field study显示文摘Background: Alterations in hematology, especially erythroid changes, may be involved in acute mountain sickness(AMS) at high altitude. This study aimed to identify the relationship between excessive erythrocytosis and AMS following different durations of high-altitude exposure.Methods: A total of 692 healthy young Chinese men were recruited for the study in June and July of 2012 and were divided into the following five groups: I) the 24-h group(24 hours after arrival at Lhasa, 3,700 m, n=261); II) the 7-d group(exposed at Lhasa, 3,700 m for seven days, n=99); III) the re-exposure group(re-exposed at Yang Bajing, 4,400 m for seven days after >1 year of acclimation at 3,700 m, n=94); IV) the acclimated group(>1 year of acclimation at 3,700 m, Lhasa, n=42); and V) the sea-level control(control group, Chengdu, n=196). Case report forms were used to record the subjects' demographic information and AMS-related symptoms. All of the subjects underwent routine blood tests.Results: The red blood cell(RBC) count fell slightly but was not significant upon acute exposure to high altitude, whereas the hemoglobin concentration([Hb]) increased significantly. After high-altitude re-exposure, both of the [Hb] and RBC count showed significant increases. The incidence of AMS was 65.1%, 26.3% and 51.1%, respectively in the 24-h, 7-d and re-exposure groups. The [Hb](P=0.024) and hematocrit(P=0.017) were greater in the AMS+ individuals than in the AMS– individuals in 7-d group. A correlation analysis revealed that the [Hb] and hematocrit were closely related with AMS score in 7-d and re-exposure groups, while the RBC showed a correlation with AMS score only in the re-exposure group. The AMS incidence was lowest when the [Hb] was between 140 and 160 g/L in the 24-h and 7-d groups.Conclusions: AMS is associated with both [Hb] and excessive erythrocytosis. Additionally, our findings indicate the existence of an optimal [Hb] for preventing AMS. | Xiao-Han Ding Ji-Hang Zhang Bin Cui Lan Huang | 2014 | Journal of Medical Colleges of PLA(China)2014，29，2： | 4 |
| 2 | 急性高原暴露左心房容积变化与高原病的关系显示文摘目的:探讨急性高原暴露发生急性高原病时左心房的容积变化与急性高原病的关系。方法:选择初上高原发生急性高原病人员作为高原病组,同期选择性别、年龄匹配的未发生高原反应人员作为对照组,采用超声心动图检测两组每搏输出量(SV)、心输出量(CO)、左心房容积指数(LAVI)、二尖瓣下血流速度E以及A等指标。结果:上高原前两组SV、CO、LAVI、E、A以及E/A等无统计学差异(P均>0.05);与上高原前比较,高原病组上高原后SV、E峰、E/A减小,CO、A峰、LAVI增加(P<0.05),对照组上高原后E峰、E/A减小,CO、A峰增加(P均<0.05),LAVI以及SV无显著变化(P>0.05);与对照组比较,上高原后,高原病组LAVI增加(P<0.05),SV、A峰减小(P<0.05)。结论:急性高原暴露后发生急性高原病可能和左心房功能减低存在一定的关系。 | 孙艳丹 王银 邹晓娟 苏军芳 | 2016 | 西北国防医学杂志2016，37，2： | 1 |
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