共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Medical treatment for gastro-entero-pancreatic neuroendocrine tumours显示文摘Gastro-entero-pancreatic neuroendocrine neoplasms(GEPNENs) represents a various family of rare tumours. Surgery is the first choice in GEP-NENs patients with localized disease whilst in the metastatic setting many other treatment options are available. Somatostatin analogues are indicated for symptoms control in functioning tumours. Furthermore they may be effective to inhibit tumour progression. GEP-NENs pathogenesis has been extensively studied in the last years therefore several driver mutations pathway genes have been identified as crucial factors in their tumourigenesis. GEP-NENs can over-express vascular endothelial growth factor(VEGF), basic-fibroblastic growth factor, transforming growth factor(TGF-α and-β), platelet derived growth factor(PDGF), insulin-like growth factor-1(IGF-1) and their receptors PDGF receptor, IGF-1 receptor, epidermal growth factor receptor, VEGF receptor, and c-kit(stem cell factor receptor) that can be considered as potential targets. The availability of new targeted agents, such as everolimus and sunitinib that are effective in advanced and metastatic pancreatic neuroendocrine tumours, has provided new treatment opportunities. Many trials combing new drugs are ongoing. | Rossana Berardi Francesca Morgese Mariangela Torniai Agnese Savini Stefano Partelli Silvia Rinaldi Miriam Caramanti Consuelo Ferrini Massimo Falconi Stefano Cascinu | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 2 | 放射性核素标记Exendin-4类似物用于胰岛素瘤显像的研究进展显示文摘胰岛素瘤是常见的胰腺内分泌肿瘤,常规方法难以检测。核素显像如单光子断层扫描(SPECT)和正电子断层扫描(PET)具有无创、敏感度高、特异性好等优势,为胰岛素瘤的诊断提供了新技术。胰高血糖素样肽-1受体(GLP-1R)在胰岛素瘤中高表达,是潜在的肿瘤靶点。Exendin-4作为GLP-1R激动剂,可与受体特异性结合。本文介绍放射性核素标记GLP-1R激动剂(Exendin-4)类似物的进展及在胰岛素瘤显像研究中的应用。 | 许清 杨敏 罗世能 | 2015 | 肿瘤防治研究2015，42，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员