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| 1 | 含奥沙利铂方案与FOLFIRI方案一线化疗对K-ras基因不同状态晚期大肠癌患者的疗效及预后影响比较显示文摘目的探究含奥沙利铂方案与FOLFIRI方案对Ⅳ期结直肠癌化疗疗效及预后影响的差别与K-ras基因状态的关系。方法收集2010年1月至2012年1月的118例接受含奥沙利铂方案或FOLFIRI方案化疗的Ⅳ期结直肠癌患者临床资料,统计患者的治疗有效率(ORR)、疾病控制率(DCR)、无进展生存时间(PFS)和总生存期(OS)。采用χ2检验比较各组临床因素差别和两种治疗方案的有效率及疾病控制率,采用Kaplan-Meier法比较无进展生存时间以及总生存期。结果 118例患者中,接受含奥沙利铂方案化疗的K-ras突变型患者PFS及OS较接受FOLFIRI方案化疗患者延长(P=0.048;P=0.037),ORR及DCR较接受FOLFIRI方案化疗患者无明显差别(P=0.961;P=0.931)。接受含奥沙利铂方案化疗的K-ras野生型患者ORR、DCR、PFS及OS较接受FOLFIRI方案化疗患者无明显差别(P=0.900;P=0.802;P=0.738;P=0.904)。结论采用含奥沙利铂方案一线化疗较FOLFIRI方案对K-ras突变型Ⅳ期结直肠癌患者更有优势,而对于K-ras野生型Ⅳ期结直肠癌患者,含奥沙利铂方案与FOLFIRI方案疗效及预后情况相当。 | 徐可 王少龙 姜鹤群 张杰 | 2015 | 肿瘤防治研究2015，42，3： | 8 |
| 2 | Personalizing medicine for metastatic colorectal cancer:Current developments显示文摘Metastatic colorectal cancer(mCRC)is still one of the tumor types with the highest incidence and mortality.In 2012,colorectal cancer was the second most prevalence cancer among males(9%)and the third among females(8%).In this disease,early diagnosis is important to improve treatment outcomes.However,at the time of diagnosis,about one quarter of patients already have metastases,and overall survival of these patients at 5-years survival is very low.Because of these poor statistics,the development of new drugs against specific targets,including the pathway of angiogenesis,has witnessed a remarkable increase.So,targets therapies through epidermal growth factor and its receptor and also KRAS pathways modulation acquired a main role whether in association with standard chemotherapy and radiotherapy.With the current knowledge in the field of molecular biology,including genetic mutations and polymorphisms,we know better why patients respond so differently to the same treatments.So,in the future we can develop increasingly personalized treatments to the patient and not the disease.This review aims to summarize some molecular pathways and their relation to tumor growth,as well as novel targeted developing drugs and recently approved for mCRC. | rea Marin Marques Alice Turner Ramon rade de Mello | 2014 | World Journal of Gastroenterology2014，20，30： | 2 |
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