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		题名	作者	年代	出处	被引量
	1	法舒地尔对大鼠脑缺血/再灌注神经元细胞凋亡作用的研究显示文摘目的探讨法舒地尔干预后对大鼠脑缺血/再灌注神经元细胞是否具有抗凋亡作用。方法解剖SD大鼠分离脑缺血/再灌注神经元细胞细胞,不同浓度法舒地尔干预后,运用TUNEL法检测大鼠脑缺血/再灌注神经元细胞的凋亡情况。结果法舒地尔能明显减少TUNEL染色阳性细胞数,且浓度越高作用越明显。结论法舒地尔干预后对大鼠脑缺血/再灌注神经元细胞具有抗凋亡作用。	郭淼	2015	中西医结合心血管病电子杂志2015，3，26：	0
	2	End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899显示文摘AIM: To compare the therapeutic efficacy of SAR407899 with the current standard treatment for hypertension [an angiotensin converting enzyme(ACE)-inhibitor and a calcium channel blocker] and compare the frequency and severity of the hypertension-related end-organ damage. METHODS: Long-term pharmacological characterization of SAR407899 has been performed in two animal models of hypertension, of which one is sensitive to ACE-inhibition and the other is insensitive [deoxycorticosterone acetate(DOCA)]. SAR407899 efficiently lowered high blood pressure and significantly reduced late-stage end organ damage as indicated by improved heart, kidney and endothelial function and reduced heart and kidney fibrosis in both models of chronic hypertension. RESULTS: Long term treatment with SAR407899 has been well tolerated and dose-dependently reduced elevated blood pressure in both models with no signs of tachyphylaxia. Blood pressure lowering effects and protective effects on hypertension related end organ damage of SAR407899 were superior to ramipril and amlodipine in the DOCA rat. Typical end-organ damage was significantly reduced in the SAR407899-treated animals. Chronic administration of SAR407899 significantly reduced albuminuria in both models. The beneficial effect of SAR407899 was associated with a reduction in leukocyte/macrophage tissue infiltration. The overall protective effect of SAR407899 was superior or comparable to that of ACE-inhibition or calciumchannel blockade. Chronic application of SAR407899 protects against hypertension and hypertension-induced end organ damage, regardless of the pathophysiological mechanism of hypertension. CONCLUSION: Rho-kinases-inhibition by the SAR407899 represents a new therapeutic option for the treatment of hypertension and its complications.	Matthias Lohn Oliver Plettenburg Aimo Kannt Markus Kohlmann Armin Hofmeister Dieter Kadereit Peter Monecke Alexander Schiffer Anke Schulte Hartmut Ruetten Yuri Ivashchenko	2015	World Journal of Cardiology2015，7，1：	0

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