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| 1 | 大鼠脑动脉瘤形成过程中MMP-2、MMP-9动态变化及多西环素对其的抑制作用显示文摘目的观察MMP-2及MMP-9在大鼠脑动脉瘤形成过程中的动态变化,以及多西环素对其的抑制作用。方法选取雄性SD大鼠90只,随机分为对照组(n=10)、模型组(n=40)和治疗组(n=40);模型组和治疗组建立肾性高血压模型,治疗组予以多西环素(1.5 mg/kg)混入饲料喂养,模型组仅给普通饲料;对照组模拟手术,普通饲料喂养。光镜下观察各组脑动脉瘤形成情况及动脉瘤壁的病理变化,采用免疫组化及RT-PCR方法检测对照组和模型组、治疗组术后1、2、3、4个月时脑动脉壁组织MMP-2及MMP-9表达。结果对照组未产生脑动脉瘤,其动脉壁MMP-2及MMP-9无明显表达;模型组随着术后时间的推移,脑动脉壁MMP-2及MMP-9表达增加,术后1个月达最高峰并持续至4个月;治疗组未见明显脑动脉瘤产生,仅发现部分瘤前病变,其动脉壁MMP-2及MMP-9的表达明显减少,P均<0.01。结论大鼠脑动脉壁MMP-2及MMP-9过度表达能导致脑动脉瘤,多西环素能抑制该过程。 | 付强 吕涛 关俊宏 | 2015 | 山东医药2015，55，20： | 3 |
| 2 | Topographic patterns of vascular disease: HOX proteins as determining factors?显示文摘Steadily increasing evidence supports the idea that genetic diversities in the vascular bed are, in addition to hemodynamic influences, a major contributing factor in determining region-specific cardiovascular disease susceptibility. Members of the phylogenetically highly conserved Hox gene family of developmental regulators have to be viewed as prime candidates for determining these regional genetic differences in the vasculature. During embryonic patterning, the regionally distinct and precisely choreographed expression patterns of HOX transcription factors are essential for the correct specification of positional identities. Apparently, these topographic patterns are to some degree retained in certain adult tissues, including the circulatory system. While an understanding of the functional significance of these localized Hox activities in adult blood vessels is only beginning to emerge, an argument can be made for a role of Hox genes in the maintenance of vessel wall homeostasis and functional integrity on the one hand, and in regulating the development and progression of regionally restricted vascular pathologies, on the other. Initial functional studies in animal models, as well as data from clinical studies provide some level of support for this view. The data suggest that putative genetic regulatory networks of Hox-dependent cardiovascular disease processes include genes of diverse functional categories(extracellular matrix remodeling, transmembrane signaling, cell cycle control, inflammatory response, transcriptional control, etc.), as potential targets in both vascular smooth muscle and endothelial cells, as well as cell populations residing in the adventitia. | Richard P Visconti Alexander Awgulewitsch | 2015 | World Journal of Biological Chemistry2015，6，3： | 2 |
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