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| 1 | Toxicity of Mexican native plant extracts against larvae of Aedes aegypti(Diptera: Culicidae)显示文摘Objective: To evaluate five indigenous Mexican plants [Hippocratea excelsa, Hippocratea celastroides, Argemone mexicana(A. mexicana), Tagetes lucida, and Pseudosmodingium perniciosum(P. perniciosum)] toxicity against the fourth instar larvae of the dengue primary vector, Aedes aegypti(A. aegypti).Methods: Each plant part was treated successively with hexane, ethyl acetate, acetone, and methanol to extract potential active components of the plants against the dengue vector.Results: There was a range of toxicity at 24 or 48 h post-exposure for the different plant parts and organic solvent used(LC50 values ranged between 20 and 890 μg/mL). Extracts from seeds of A. mexicana(hexane washing with methanol and acetone) and stem-bark of P. perniciosum(hexane) showed highest toxicity to Ae. aegypti larvae at 48 h post-exposure(LC50 values were80, 50, and 20 μg/mL, respectively), thus making them potential candidates as biolarvicides.Efforts are on-going to characterize the bioactive components of the extracts, through chromatography, for their use as biological tools for the control of the primary dengue vector.Conclusions: A. mexicana and P. perniciosum are good candidates to combat the dengue vector, Ae. aegypti, as they were highly toxic to the larvae. | Rosario Ruiz-Guerrero Mario Alberto Rodríguez-Pérez Mariano Norzagaray-Campos | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，4： | 0 |
| 2 | Current perspectives on dengue episode in Malaysia显示文摘To Prevalence of dengue transmission has been alarmed by an estimate of 390 million infections per annum.Urban encroachment,ecological disruption and poor sanitation are all contributory factors of increased epidemiology.Complication however arises from the fact that dengue virus inherently exists as four different serotypes.Secondary infection is often manifested in the more severe form,such that antibody-dependent enhancement(ADE) could aggravate ailment by allowing pre-existing antibodies to form complexes with infecting viruses as means of intrusion.Consequently,increased viraemic litter and suppression of antiviral response are observed.Deep concerns are thus expressed in regards to escalating trend of hospitalisation and mortality rates.In Malaysia,situation is exacerbated by improper clinical management and pending vector control operations.As a preparedness strategy against the potential deadly dengue pandemic,the call for development of a durable and costeffective dengue vaccine against all infecting serotypes is intensified.Even though several vaccine candidates are currently being evaluated in clinical trials,uncertainties in regards to serotypes interference,incomplete protection and dose adequacy have been raised.Instead of sole reliance on outsourcing,production of local vaccine should be considered in coherent to government's efforts to combat against dengue. | Ee Leen Pang Hwei-San Loh | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 0 |
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