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| 1 | Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome显示文摘Serotonin(5-HT) and the serotonin transporter(SERT) have earned a tremendous amount of attention regarding the pathogenesis of irritable bowel syndrome(IBS). Considering that enteric 5-HT is responsible for the secretion, motility and perception of the bowel, the involvement of altered enteric 5-HT metabolism in the pathogenesis of IBS has been elucidated. Higher 5-HT availability is commonly associated with depressed SERT mR NA in patients with IBS compared with healthy controls. The expression difference of SERT between IBS patients and healthy controls might suggest that SERT plays an essential role in IBS pathogenesis, and SERT was expected to be a novel therapeutic target for IBS. Progress in this area has begun to illuminate the complex regulatory mechanisms of SERT in the etiology of IBS. In this article, current insights regarding the regulation of SERT in IBS are provided, including aspects of SERT gene polymorphisms, microR NAs, immunity and inflammation, gut microbiota, growth factors, among others. Potential SERT-directed therapies for IBS are also described. The potential regulators of SERT are of clinical importance and are important for better understanding IBS pathophysiology and therapeutic strategies. | Duo-Chen Jin Hai-Long Cao Meng-Que Xu Si-Nan Wang Yu-Ming Wang Fang Yan Bang-Mao Wang | 2016 | World Journal of Gastroenterology2016，22，36： | 10 |
| 2 | 易蒙停对结肠切除后青紫兰兔结肠黏膜中5-HT、CgA阳性细胞影响的实验研究显示文摘目的通过易蒙停(盐酸洛哌丁胺)对结肠黏膜5-羟色胺(5-hydroxy tryptamine,5-HT)、嗜铬粒蛋白A(Chromogranin A,CgA)阳性细胞数的影响,初步探讨易蒙停对肠道内分泌细胞的作用情况。方法切除青紫兰兔结肠后,随机分成两组,分别给予空白、易蒙停治疗14d,处死后取吻合口处结肠。免疫组化法检测正常结肠、吻合口处结肠黏膜中5-HT、CgA阳性细胞。结果正常组、术后空白对照组、给药组5-HT阳性细胞数分别为10.40±2.22,26.27±2.35,18.20±2.71;CgA阳性细胞数分别为20.60±5.34,51.51±6.13,36.10±5.34;各组间两两比较差异均有统计学意义(P〈0.0 1)。结论易蒙停可致结肠切除后青紫兰兔结肠黏膜5-HT、CgA阳性细胞数的减少。 | 涂小煌 陈志耀 冯昌银 | 2009 | 中国实用外科杂志2009，29，S1： | 0 |
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