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1Heterogeneity across the murine small and large intestine显示文摘The small and large intestine of the gastrointestinal tract(GIT) have evolved to have discrete functions with distinct anatomies and immune cell composition.The importance of these differences is underlined when considering that different pathogens have uniquely adapted to live in each region of the gut.Furthermore,different regions of the GIT are also associated with differences in susceptibility to diseases such as cancer and chronic inflammation.The large and small intestine,given their anatomical and functional differences,should be seen as two separate immunological sites.However,this distinction is often ignored with findings from one area of the GIT being inappropriately extrapolated to the other.Focussing largely on the murine small and large intestine,this review addresses the literature relating to the immunology and biology of the two sites,drawing comparisons between them and clarifying similarities and differences.We also highlight the gaps in our understanding and where further research is needed.Rowann Bowcutt Ruth Forman Maria Glymenaki Simon Richard Carding Kathryn Jane Else Sheena Margaret Cruickshank 2014World Journal of Gastroenterology2014,20,41:2
2动物消化道上皮屏障在控制肠内环境稳定中的作用显示文摘动物肠道内部与外界环境之间相互作用,而单层上皮细胞将肠道微生物与下层肠组织隔离形成肠道上皮屏障。目前研究发现肠道上皮不仅起屏障作用,对收集体内外信号和协调免疫应答亦至关重要。本文对肠道上皮屏障如何与共生菌、病原微生物及免疫细胞间的相互作用以及调节内环境稳定进行概述,旨在为动物肠道黏膜免疫机制的揭示提供参考。李雨宸 王春凤 杨桂连 2015中国兽医学报2015,35,6:1
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