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| 1 | Monitoring of clinical islet transplantation显示文摘Islet transplantation has recently emerged as one of the most promising therapeutic approaches to improving glycometabolic control in diabetic patients.The Edmonton trials demonstrated a marked improvement in the short-term rate of success of islet transplantation,with an 80% rate of insulin-independence being at 1 year after transplantation,as reported by several institutions worldwide.Unfortunately,this rate consistently decreases to 10% by 5 years post-transplantation.1 Other data reported that less than half of the patients achieved insulin independence at 1 year and <15% remained insulin independent at 2 years.2It is not clear whether this decline in insulin independence is the result of islet loss.Also unclear are the mechanisms that underlie the deterioration of graft function,though possibilities include auto or alloimmune destruction,immunosuppressant toxicity,or a progressive disruption of insulin secretion.Several questions with respect to islet transplantation remain regarding why and when insulin independence is attained,the effective volume of marginal islet mass,and the mechanism of loss of islet mass following transplantation.As such,there is an urgent need for efficient monitoring tools to label and track islets,detect graft damage,and monitor the long-term function and survival of transplanted islets.Furthermore,because complications of islet transplantation may be either immediate or delayed as a consequence of the migration of engrafted islets to the liver or as a side effect of immunosuppressive therapy,routine post-transplantation imaging is important to detect complications that are not apparent with clinical or laboratory examinations.3 Successful monitoring of the stability and function of the graft and graft-related complications will assist in the evaluation of various immunosuppressive regimens and islet delivery strategies and ultimately assist in optimizing the islet transplantation procedure.In this article,we summarize the recent advances in the monitoring of islet post-transplantation,as shown in Table 1. | HE Si-rong MAI Gang LU Yan-rong CHEN You-nan ZHANG Shuang CHENG Jing-qiu | 2013 | Chinese Medical Journal2013，，3： | 0 |
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