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		题名	作者	年代	出处	被引量
	1	Resolution pattern of jaundice among children presenting with severe malaria in rural South-West Nigeria显示文摘Objective:To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether.Methods:Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities.They were divided into two groups:'Q' and 'A',receiving quinine and artemether.respectively.Jaundice was assessed by clinical examination.Results:Sixteen out of 32 children recruited(representing50%) presented with jaundice on the dav of recruitment.The mean age was(7.00±2.56) years.On day 3,tour patients in 'A' and six patients in 'O' had jaundice.By day 7.no child had jaundice.Conclusion:The study has shown that hoth drugs resolve jaundice although artemether relatively resolves it faster by the third day.	Osonuga OA Osonuga A Osonuga AA Osonuga IO	2012	Asian Pacific Journal of Tropical Biomedicine2012，2，7：	1
	2	Comparison of protein patterns between Plasmodium falciparum mutant clone T9/94-M1-1(b3) induced by pyrimethamine and the original parent clone T9/94显示文摘Objective:To compare the protein patterns from the extracts of the mutant clone T9/94-M1-1(b3)induced by pyrimethamine,and the original parent clone T9/94 following separation of parasite extracts by two-dimensional electrophoresis(2-DE).Methods:Proteins were solubilized and separated according to their charges and sizes.The separated protein spots were then detected by silver staining and analyzed for protein density by the powerful image analysis software.Results:Differentially expressed protein patterns(up—or down-regulation)were separated from the extracts from the two clones.A total of 223 and 134 protein spots were detected from the extracts of T9/94 and T9/94-M1-1(b3)clones,respectively.Marked reduction in density of protein expression was observed with the extract from the mutant(resistant)clone compared with the parent(sensitive)clone.A total of 25 protein spots showed at least two-fold difference in density,some of which exhibited as high as ten-fold difference.Conclusions:These proteins may be the molecular targets of resistance of Plasmodium falciparum to pyrimethamine.Further study to identify the chemical structures of these proteins by mass spectrometry is required.	Kanchana Rungsihirunrat Wanna Chaijaroenkul Napapom Siripoon Aree Seugorn Sodsri Thaithong Kesara Na-Bangchang	2012	Asian Pacific Journal of Tropical Biomedicine2012，2，1：	0

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