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		题名	作者	年代	出处	被引量
	1	Effect of ERBB2 expression on invasiveness of glioma TJ905 cells显示文摘Objective:To investigate the influence and possible mechanism of ERBB2 expression on the invasiveness of glioma cells.Methods:Glioma TJ905 cells were separated and cultured.ERBB2shRNA and overexpressing vectors were constructed,which were then transfected.The ERBB2expression was up-regulated or down-regulated.Changes of invasiveness of TJ905 cells were detected by Transwell assay,and the expressions of matrix metalloprotease(MMP)-2 and MMP-9were measured by Western bolt.Results:ERBB2 shRNA transfection vector could effectively inhibit expression of ERBB2:while ERBB2 overexpressing vector transfection could significantly improve the expression of ERBB2 in TJ905 cells.Transwell assay showed that when ERBB2expression was down-regulated,the invasiveness of TJ905 cells was notably decreased;when ERBB2 expression was up-regulated,the invasiveness of TJ905 cells was markedly increased.Meanwhile.Western blot indicated that down-regulating ERBB2 inhibited the expression of MMP-2 and MMP-9,while up-regulating ERBB2 enhanced their expressions.Conclusions:ERBB2 expression is closely related in the invasiveness of glioma TJ905 cells.	Gao-Feng Xu Wan-Fu Xie	2013	Asian Pacific Journal of Tropical Medicine2013，6，12：	0

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