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| 1 | 生物可降解温敏性物理交联水凝胶的研究进展显示文摘近年来,原位形成的水凝胶体系已有诸多报道,通过溶剂交换、紫外线照射、离子浓度、pH值和温度的改变可原位诱导凝胶化转变。温敏性凝胶体系通常具有微妙的疏水-亲水两亲性平衡,在不需要有机溶剂、偶联剂和其它外界刺激的条件下,仅通过改变环境温度即可触发凝胶化相转变。生物可降解的温敏性水凝胶具有广阔的应用前景,既能作为药物缓释与输送的载体,也可用作组织再生的支架等生物医学材料。文中根据凝胶基体共聚物拓扑结构的不同,详细综述了近年生物可降解温敏性物理交联水凝胶的研究进展,及其化学物理结构与凝胶化行为、凝胶特性之间的内在联系。 | 毛海良 潘鹏举 单国荣 包永忠 | 2014 | 高分子材料科学与工程2014，30，11： | 2 |
| 2 | Preparation of novel biodegradable pHEMA hydrogel for a tissue engineering scaffold by microwave-assisted polymerization显示文摘Objective:To prepare a novel biodegradable poly(2-hydroxyethylmethacrilate)(pHEMAt hydrogel as tissue engineering scaffold.Methods:The pHEMA hydrogel was synthesized by microwaveassisted polymerization using 2-hydroxyethyl methacrylale(IIEMA)as the raw material,potassium persulfate as the initiator,and PCI.X as the cross-linking additive.The hvdrogels was characterized with FTIR and NMR spectroscopy.The physical and chemical properties of the prepared hydrogel were evaluated,and its degradation performance was tested.The cytotoxicity of the optimum composite hydrogel was measured by an MTT assay to confirm the feasibility of its use in tissue engineering.Results:The optimum conditions under which the hydrogel was prepared by microwave-assisted polymerization are as follows:1.5 g cross-linking additive,0.3 g initiator,reaction temperature of 80°C,and microwave power of 800 W.Degradation studies showed good degradation profiles with 75%in 17 days.Additionally,the hydrogels did not elicit any cytotoxic response in in vitro cytotoxic assays.Conclusion:A biodegradable pIIEMA hydrogel was successfully prepared by microwave-assisted polymerization,as confirmed from FTIR and NMR results.The hydrogel shows promising applications in tissue engineering,and its healing ability and biocompatibilily will be evaluated in detail in the future. | Li Zhang Gen-Jian Zheng Ya-Tong Guo Lan Zhou Jie Du Hong He | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，2： | 1 |
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