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| 1 | Redox therapeutics in hepatic ischemia reperfusion injury显示文摘Ischemia-reperfusion plays a major role in the injury experienced by the liver during transplantation. Much work has been done recently investigating the role of redox species in hepatic ischemia-reperfusion. As animal models are better characterized and developed, and more insights are gained into the pathophysiology of hepatic ischemia reperfusion injury in humans the questions into exactly how oxidants participate in this injury are becoming more refined. These questions include effects of cellular location, timing of injury, and ability of therapeutics to access this site are increasing our appreciation of the complexity of ischemia reperfusion and improving attempts to ameliorate its effects. In this review, we aim to discuss the various methods to alter redox chemistry during ischemia reperfusion injury and future prospects for preventing organ injury during hepatic ischemia reperfusion. | Rakesh P Patel John D Lang Alvin B Smith Jack H Crawford | 2014 | World Journal of Hepatology2014，6，1： | 9 |
| 2 | 粗糠柴毒素对SD大鼠抗心肌缺血-再灌注损伤的作用显示文摘目的研究粗糠柴毒素对抗心肌缺血-再灌注损伤的作用。方法结扎雄性SD大鼠心脏冠状动脉左前降支40 min造成心肌缺血,剪断结扎线进行120 min再灌注,以此构建心肌缺血-再灌注模型。实验组大鼠缺血处理前给予1μmol/L粗糠柴毒素处理,对照组予生理盐水处理。抽取血液检测血清乳酸脱氢酶(LDH)及肌酸激酶(CK-MB)活性。随后取出心脏并取样,将细胞裂解并离心,对提取物进行Western印迹测定,其中乙醛脱氢酶(ALDH)2磷酸化比例。结果实验组LDH活性(4 079.6±88.3)U/L,对照组(5 703.7±451.9)U/L。实验组CK-MB活性(3 228.5±257.4)U/L,对照组(4 433.4±319.9)U/L。实验组磷酸化ALDH2占总ALDH2比例(0.340±0.032),对照组(0.101±0.037)。两组各指标均存在显著差异(均P<0.05)。结论粗糠柴毒素可显著提升缺血-再灌注心肌的ALDH2磷酸化水平并降低血清LDH和CK-MB水平,诱导心脏保护。ALDH2激活可能参与了粗糠柴毒素的心脏保护作用。 | 李鸿博 郎小娥 | 2014 | 中国老年学杂志2014，34，10： | 1 |
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