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1Alcoholic pancreatitis:A tale of spirits and bacteria显示文摘Alcohol is a major cause of chronic pancreatitis.About5%of alcoholics will ever suffer from pancreatitis,suggesting that additional co-factors are required to trigger an overt disease.Experimental work has implicated lipopolysaccharide,from gut-derived bacteria,as a potential co-factor of alcoholic pancreatitis.This review discusses the effects of alcohol on the gut flora,the gut barrier,the liver-and the pancreas and proposes potential interventional strategies.A better understanding of the interaction between the gut,the liver and the pancreas may provide valuable insight into the pathophysiology of alcoholic pancreatitis.Alain Vonlaufen Laurent Spahr Minoti V Apte Jean-Louis Frossard 2014World Journal of Gastrointestinal Pathophysiology2014,5,2:3
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