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| 1 | 肠道菌群与心血管疾病的研究进展显示文摘肠道菌群被喻为人体的'微生物器官',参与、辅助宿主能量代谢,调节先天与获得性免疫,构成人体肠道的生物学屏障〔1〕。研究显示,肠道菌群结构紊乱不仅与消化系统、内分泌系统、肿瘤等疾病相关,而且与心血管疾病的发生相关。肠道菌群可能通过参与调解宿主胆固醇代谢、氧化应激和炎症导致动脉粥样硬化发生,从而促进心血管疾病的发生、发展。1肠道菌群概述人体携带细菌数量1014,基因数量300万个,是人类自身基因的100倍,总重量1.275 kg,其中1.0 | 赵莹 付军 | 2014 | 中国老年学杂志2014，34，5： | 18 |
| 2 | Intestinal barrier: A gentlemen's agreement between microbiota and immunity显示文摘Our body is colonized by more than a hundred trillion commensals, represented by viruses, bacteria and fungi. This complex interaction has shown that the microbiome system contributes to the host's adaptation to its environment, providing genes and functionality that give flexibility of diet and modulate the immune system in order not to reject these symbionts. In the intestine,specifically, the microbiota helps developing organ structures, participates of the metabolism of nutrients and induces immunity. Certain components of the microbiota have been shown to trigger inflammatory responses, whereas others, anti-inflammatory responses.The diversity and the composition of the microbiota,thus, play a key role in the maintenance of intestinal homeostasis and explain partially the link between intestinal microbiota changes and gut-related disorders in humans. Tight junction proteins are key molecules for determination of the paracellular permeability. In the context of intestinal inflammatory diseases, the intestinal barrier is compromised, and decreased expression and differential distribution of tight junction proteins is observed. It is still unclear what is the nature of the luminal or mucosal factors that affect the tight junctionproteins function, but the modulation of the immune cells found in the intestinal lamina propria is hypothesized as having a role in this modulation. In this review,we provide an overview of the current understanding of the interaction of the gut microbiota with the immune system in the development and maintenance of the intestinal barrier. | Andrea Moro Caricilli Angela Castoldi Niels Olsen Saraiva Cmara | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，1： | 11 |
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