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| 1 | 奥沙利铂联合替尼泊甙对胃癌BGC-823细胞的生长抑制和诱导凋亡的协同作用(英文)显示文摘Objective:The aim of this study was to investigate the synergistic effects of oxaliplatin and teniposide on proliferation and apoptosis of gastric cancer cell line BGC-823.Methods:MTT assay was carried to examine the inhibition rate of oxaliplatin and teniposide on gastric cancer cell line BGC-823 with various concentrations separately and associatively.The apoptosis rate of BGC-823 cells under the treatment of oxaliplatin or/and teniposide was examined by flow cytometry.The expression level of livin, an apoptosis-associated protein, was explored by western blot.Results:Oxaliplatin or teniposide could remarkably inhibit the BGC-823 gastric cancer cell growth with a dose-response manner, separately and associatively.The inhibition rate of oxaliplatin combined with teniposide on BGC-823 cells was higher than that of single oxaliplatin or single teniposide(P < 0.05), with 0.46 as combination index(CI) value.The apoptosis rates of cells treated by oxaliplatin for 12 h, 24 h and 48 h were 6.13%, 13.86% and 21.48%, respectively, while which of teniposide were 4.60%, 10.72%, 17.07%.But when the two medicines were carried associatively, the apoptosis rates for 12 h, 24 h and 48 h were 11.73%, 24.14% and 44.75%, respectively.Western blot showed that the expression level of livin was more down-regulated when cells were treated by oxaliplatin + teniposide than by oxaliplatin singly.Conclusion:The combination of oxaliplatin and teniposide can exert a synergistic effect on gastric cancer cell BGC-823. | Wang Ma Ming Gao Wei He Qingxia Fan | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 1 |
| 2 | 脑肿瘤分级与nNOS和线位体中的cyt c的关系(英文)显示文摘Objective: The aim of this study was to investigate the association between neuronal nitric oxide synthase (nNOS) and the expression level of Cytochrome C (Cyt-c) in mitochondria. Methods: The pathological diagnosis of glioma and tumor classification was by HE staining, and we use immunohistochemistry method to analyse the level of nNOS in different pathological grade glioma and the expression level of Cyt-c in mitochondria meanwhile. Results: The levels of nNOS were highest in grade III tumors, moderate in grade II tumors, and lowest different in grade I tumors. There was significant difference of the nNOS levels among different pathological grade tumors (P < 0.05). Furthermore, the similar phenomenon was observed in the expression level of Cyt-c in mitochondria (P < 0.05). Conclusion: The expression level of nNOS and Cyt-c in mitochondria was significantly related to the pathological grade of glioma. | Na Li Zongze Guo Gangyu Li Weicheng Lu Weixin Zhang Yunjie Wang | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，10： | 0 |
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