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| 1 | 重楼属植物化学成分及药理活性研究进展显示文摘重楼属Paris隶属于百合科(Liliaceae),全世界共有24个种,我国有19个种,分布于云南、贵州、四川等西南地区。其主要化学成分有甾体皂苷类、黄酮类、三萜类、脂肪酸类等,具有抗肿瘤、抗菌、止血、驱虫等药理作用。总结了重楼属植物系统分类、化学成分和药理作用的研究现状,以期为该属植物的进一步研究提供参考。 | 杨远贵 张霁 张金渝 王元忠 | 2016 | 中草药2016,47,18: | 85 |
| 2 | 重楼属药用植物皂苷类化学成分及其生源途径的研究进展显示文摘重楼属药用植物的皂苷类成分丰富,种类多样,具有重要的研究价值。以近几年发表的国内外文献为依据,对重楼属植物皂苷类化学成分方面的研究进展做一综述,并比较了各种重楼所含甾体皂苷的差异性和同一性,同时对各类型皂苷的生源途径进行了探讨。由于南重楼与药用重楼化学成分极为相似,有望作为药用重楼的替代植物;薯蓣皂苷元可能是生物体内合成其他甾体皂苷的关键物质。 | 黄贤校 高文远 满淑丽 赵志勇 | 2009 | 中草药2009,40,3: | 50 |
| 3 | 重楼属植物化学成分、药理作用研究进展及质量标志物预测分析显示文摘重楼为我国传统的中药材,主要分布于我国云南、四川、贵州等地区,因其具有镇痛、止血、抗肿瘤、抗氧化、免疫调节等作用,在药品及保健品中有广泛的应用。但是其品种众多,药效差异明显,因此重楼的品质评价成为制约其开发利用亟需解决的问题之一。对重楼属植物的化学成分、药理活性进行系统整理,基于化学成分特有性、化学成分与药效相关性、传统药性、化学成分可测性几个方面对重楼属植物的质量标志物(Q-marker)进行预测分析,为该属植物的质量评价研究提供科学依据。 | 管鑫 李若诗 段宝忠 王莹 范敏 王双 张海珠 夏从龙 | 2019 | 中草药2019,50,19: | 49 |
| 4 | 重楼属植物的研究进展显示文摘重楼属植物的化学成分类型复杂药理活性多样,极具药用价值。本文就近年来重楼属植物的化学成分和药理活性研究进展作一综述。 | 于素强 武毅 曲玮 梁敬钰 | 2011 | 海峡药学2011,23,5: | 13 |
| 5 | 滇重楼化学成分、药理作用和临床应用研究进展显示文摘滇重楼Parispolyphyllavar.yunnanensis是临床常用的清热解毒药,具有清热解毒、消肿止痛、凉肝定惊功效,在临床实践中有广泛应用。目前从滇重楼中分离鉴定出的化学成分共125种,按照结构类型的差异可分为甾体皂苷类(72种)、C21甾体类(6种)、五环三萜类(19种)、植物甾醇类(3种)、黄酮类(7种)和其他化合物(18种),具有抗肿瘤、抑菌、抗氧化、镇痛、止血等活性。根据国内外文献报道,总结并综述了滇重楼的化学成分、药理作用和临床应用3方面的研究进展,以期为滇重楼资源的开发及临床合理应用提供参考。 | 王宇飞 江媛 杨成金 王婧 徐志超 刘颖琳 段宝忠 | 2022 | 中草药2022,53,23: | 9 |
| 6 | 云南重楼中2个脂肪酸的分离鉴定及其抑制鼻咽癌细胞活性研究显示文摘目的研究云南重楼乙醇提取物的化学成分及其抑制鼻咽癌细胞的活性。方法采用反复硅胶柱层析和Sephadex LH-20等色谱方法对云南重楼的大孔树脂60%(体积分数)乙醇洗脱部位进行分离、纯化,通过理化常数和波谱分析鉴定化合物结构;采用MTT比色法进行体外抑制鼻咽癌细胞(CNE)活性测试。结果从云南重楼的大孔树脂60%(体积分数)乙醇洗脱部位分离鉴定出2个脂肪酸类化合物,分别为(8R*,9R*,10S*,6Z)-trihydroxyoctadec-6-enoic acid(1)和methyl(9S,10R,11S)-trihydroxy-12(Z)-octadecenoate(2);活性测试结果显示,化合物2具有一定的抑制鼻咽癌细胞活性,其IC50为20.77μmol·L-1。结论 2个脂肪酸均为首次从该属植物中分离得到。 | 吴霞 张玉波 王国才 冯毅凡 李药兰 | 2014 | 广东药学院学报2014,30,6: | 5 |
| 7 | A Review of the Pharmacology, Application, Ethnopharmacology, Phytochemistry, Quality Control, Processing, Toxicology, and Pharmacokinetics of Paridis Rhizoma显示文摘Paridis Rhizoma(PR) is also known as the flower with seven leaves and one branch, PR with golden thread, etc. It tastes bitter, numb, and slightly cold and has little poison. It is often used for the treatment of external skin infection, sore throat, snake bite, fall pain, frightening convulsion, and other diseases. PR has analgesic, sedative, anti-inflammatory, hemostatic, antitumor, antibacterial, antiviral, and renal and liver protective effects;inhibition of angiogenesis;immune regulation;and antioxidant and cardiovascular effects, and antifertility and anti-early pregnancy sperm killing effects. Steroidal saponins, β-ecdysone, polysaccharides, microelements, flavonoid glycosides, and amino acids were isolated from PR. In this paper, its pharmacology, application, ethnopharmacology, phytochemistry, quality control, toxicology, and pharmacokinetics were reviewed. This information suggests that we should focus on the development of new drugs related to PR, including specific ingredients, so as to make PR play a greater therapeutic potential. At the same time, attention should be paid to the rational use of PR resources to avoid excessive using, resulting in resource shortage. Therefore, we can carry out the research on the substitutes of PR, a large-scale planting of(Paridis Rhizoma) PR, and develop the same genus of PR and other resources. So far, great progress has been made in pharmacology and phytochemistry, especially in antitumor research, and many traditional uses have been confirmed and clarified by modern pharmacological research. However, there are few studies on the mechanism of its pharmacological action and few studies on processing. To develop new drugs in the future, more studies and experiments are still needed to prove the effect of PR and explore more new effects. | Song-Tao Liu Huan Yu A-Jiao Hou Wen-Jing Man Jia-Xu Zhang Song Wang Xue-Jiao Wang Sen-Wang Zheng Xiao-Lin Su Liu Yang | 2022 | World Journal of Traditional Chinese Medicine2022,8,1: | 0 |