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| 1 | 胃间质瘤的微创治疗显示文摘1983年Mazur和Clark首先提出胃肠间质肿瘤(gastrointestinal stromal tumors,GIST)的概念,认为它是一种起源于Cajal细胞的胃肠道非上皮源性的间质肿瘤。虽然,近年来开发的酪氨酸激酶抑制剂甲磺酸伊马替尼(格列卫)在治疗复发转移或无法手术的GIST中效果显著,但是应当指出的是其反应多为部分缓解或疾病稳定,少有完全缓解的。也就是说在大部分GIST中,甲磺酸伊马替尼只能控制肿瘤生长而无法完全消灭肿瘤。胃间质瘤对化疗和放疗均不敏感,因此无论是既往或是现在,完全、彻底的根治性手术依然是原发GIST的首选治疗方法。 | 柯重伟 蔡景理 | 2007 | 外科理论与实践2007，12，6： | 13 |
| 2 | 腹腔镜下胃底黏膜下肿瘤切除术显示文摘目的评价腹腔镜下胃腔外胃底楔形切除术的可行性与安全性。方法总结分析2000年9月至2006年12月行腹腔镜下胃底切除术的84例患者的临床资料。该术式采用4孔法,手术主要步骤包括肿瘤定位、网膜游离、胃底和脾上极分离、食管贲门连接处(ECJ)显露以及用内视镜直线切割缝合器楔形切割胃底等。结果患者平均年龄59岁(32~78岁)。平均肿瘤直径(4.2±1.3)cm;肿瘤边缘距离ECJ1.1~3.0cm。84例手术均获成功,手术时间(62.6±8.9)min;术中出血(86.2±8.1)ml。无病灶遗漏,亦无并发症和手术中转。术后平均住院(5.6±0.5)d。66例患者于术后36h内恢复胃肠功能,并开始进食和下床活动。肿瘤与切缘的距离:与ECJ距离0.7—2.5cm[(1.4±0.5)cm];与另三面距离2.5~6.0cm[(4.1±1.0)cm]。84例中,平滑肌瘤29例,各型间质瘤51例,神经纤维瘤4例。平均随访(51.0±4.3)个月,无复发和转移发生。结论腹腔镜胃腔外胃底楔形切除术对胃底,尤其是后壁邻近ECJ黏膜下肿瘤是安全、简便和有效的,可避免腹腔污染、脾脏损伤以及术后食管狭窄的发生;同时,胃的切除范围也不受限。 | 柯重伟 蔡景理 陈丹磊 郑成竹 | 2008 | 中华外科杂志2008，46，23： | 6 |
| 3 | 腹腔镜手术治疗胃的胃肠间质瘤显示文摘胃肠问质瘤(gastrointestinalstromaltumor,GIST)是消化道最常见的问叶组织源性肿瘤,因该肿瘤独特的生物学行为和临床特征,外科手术和分子靶向治疗是胃GIST主要治疗手段。腹腔镜技术因其具有微创的特点。已逐渐用于胃GIST的手术治疗,并成为胃GIST外科治疗的发展趋势。本文就规范实施腹腔镜胃GIST手术中.需掌握的手术适应证、手术原则、手术方式、术中定位以及外科联合靶向药物治疗原则等进行论述,以期为临床治疗提供参考。 | 柯重伟 宋涛 丁丹 | 2013 | 中华胃肠外科杂志2013，16，10： | 5 |
| 4 | Esophageal surgery in minimally invasive era显示文摘The widespread popularity of new surgical technologies such as laparoscopy, thoracoscopy and robotics has led many surgeons to treat esophageal diseases with these methods. The expected benefits of minimally invasivesurgery(MIS) mainly include reductions of postoperative complications, length of hospital stay, and pain and better cosmetic results. All of these benefits could potentially be of great interest when dealing with the esophagus due to the potentially severe complications that can occur after conventional surgery. Moreover, robotic platforms are expected to reduce many of the difficulties encountered during advanced laparoscopic and thoracoscopic procedures such as anastomotic reconstructions, accurate lymphadenectomies, and vascular sutures. Almost all esophageal diseases are approachable in a minimally invasive way, including diverticula, gastro-esophageal reflux disease, achalasia, perforations and cancer. Nevertheless, while the limits of MIS for benign esophageal diseases are mainly technical issues and costs, oncologic outcomes remain the cornerstone of any procedure to cure malignancies, for which the long-term results are critical. Furthermore, many of the minimally invasive esophageal operations should be compared to pharmacologic interventions and advanced pure endoscopic procedures; such a comparison requires a difficult literature analysis and leads to some confounding results of clinical trials. This review aims to examine the evidence for the use of MIS in both malignancies and more common benign disease of the esophagus, with a particular emphasis on future developments and ongoing areas of research. | lapo bencini luca moraldi ilenia bartolini andrea coratti | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 5 |
| 5 | 结肠癌“蓝碟”手辅助腹腔镜与开腹手术效果比较显示文摘随着微创外科技术的发展,手辅助腹腔镜(hand-assisted laparoscopic surgery,HALS)作为一种流行的外科技术应用于结肠癌手术治疗,获得同传统结肠癌手术相当的治疗效果[1]。我们2009年5月—2010年8月应用HALS技术和新一代手辅助器"蓝碟"行结肠癌切除术39例,与同期行开腹结肠癌根治术48例相对比,总结报道如下。 | 张宪立 吕光东 付湑 | 2011 | 中国现代普通外科进展2011，14，7： | 3 |
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