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| 1 | CD10在毛囊皮脂腺囊性错构瘤中的表达显示文摘目的:检测CD10在毛囊皮脂腺囊性错构瘤(FSCH)中的表达。方法:采用免疫组化法检测6例FSCH、10例皮脂腺痣、10例皮脂腺增生症和10例正常皮肤的石蜡组织中CD10的表达。结果:CD10在FSCH皮脂腺结构中呈阳性高表达(100%),与皮脂腺痣(20%)和皮脂腺增生症(10%)相比,差异均具有统计学意义(P<0.05);CD10在FSCH间叶组织中呈低表达(20%),与皮脂腺痣(100%)和皮脂腺增生症(100%)相比同样具有统计学意义(P<0.05)。结论:CD10表达可作为鉴别FSCH与皮脂腺痣和皮脂腺增生的一个指标。 | 郑力强 韩向春 王炳胜 | 2015 | 中国麻风皮肤病杂志2015，31，5： | 2 |
| 2 | Important immunohistochemical markers for identifying sweat glands显示文摘The major adnexal structures of the skin,the sweat glands,regulate the body temperature.There are two types of sweat glands in the human body,the eccrine type,which produces the NaCl-rich solution in response to heat,and the apocrine type,which releases a lipid-rich secretion.1 Human sweat glands have many immunohistochemical markers which have close relationship with sweat-related diseases.2 Recently,although numerous immunohistochemical markers appeared in sweat glands,these biomarkers scattered in the oceans of literature without a systemic review for the relationship between the immunohistochemical marker and their functions in the counterparts of the sweat glands.It is important for identifying sweat gland-derived neoplasms that originate from or differentiate into the ducts or secretory elements of the sweat glands by immunohistochemical markers.Therefore,it is necessary to make a review of the immunohistochemical markers systematically.Actually,we try to classify the immunohistochemical markers of the sweat glands into four groups according to their protein characters and the functions associated with their presumed physiological counterparts of the sweat apparatus. | LEI Yong-hong LI Xue ZHANG Jin-qian ZHAO Jing-yu | 2013 | Chinese Medical Journal2013，，7： | 1 |
| 3 | CD10、Nestin蛋白在皮肤附属器肿瘤组织中的表达及意义显示文摘目的:探讨白细胞分化抗原簇10(CD10)、巢蛋白(Nestin)在皮肤附属器肿瘤组织中的表达及意义。方法:收集2018年1-12月本院收治的40例皮肤附属器肿瘤患者的肿瘤组织标本,另选择5例乳腺癌根治手术切除标本中远离肿瘤的皮肤为正常皮肤对照。免疫组织化学标记CD10、Nestin蛋白,观察各例肿瘤CD10、Nestin蛋白的表达情况、阳性细胞的类型和分布。结果:汗腺肿瘤、毛分化肿瘤及皮脂腺肿瘤中的CD10蛋白表达情况比较,差异有统计学意义(P=0.000),但Nestin蛋白的表达情况比较差异无统计学意义(P=0.277)。CD10在正常皮肤的皮脂腺、汗腺周围的肌上皮细胞呈阳性表达,在小汗腺和大汗腺上皮呈阴性;Nestin在正常皮肤的皮脂腺外围基底样细胞、汗腺分泌部上皮细胞呈弱阳性表达,在分化的皮脂细胞呈阴性,肌上皮细胞阳性表达。多数类型汗腺肿瘤CD10阴性,部分病例显示瘤细胞胞质内CD10阳性表达。汗管瘤的Nestin为阴性;螺旋腺瘤肌上皮部分Nestin阳性。透明细胞汗腺瘤腺腔样结构腔膜缘细胞显示Nestin颗粒状阳性。乳头状汗腺腺瘤肌上皮细胞Nestin阳性。多数类型毛分化肿瘤表达CD10及Nestin:毛母细胞瘤间质细胞CD10阳性表达,Nestun弱阳性;毛母质瘤瘤细胞CD10阳性,Nestin阳性;毛囊瘤瘤细胞CD10阳性,角化细胞Nestin阳性。皮脂腺瘤和皮脂腺癌的CD10多呈阳性表达,各例皮脂腺瘤和皮脂腺癌的Nestin表达类似,多显示为阴性或呈弱阳性表达,部分病例显示个别瘤细胞胞质内颗粒状阳性表达。结论:CD10是毛分化、皮脂腺分化皮肤附属器肿瘤的特异性标记物,干细胞标记物Nestin在这些肿瘤的表达方式可以作为肿瘤成分分化特点的参考。 | 戎锡云 | 2020 | 中国医学创新2020，17，22： | 0 |
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