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| 1 | Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma显示文摘Aberrant expression and signaling of epidermal growth factor receptor (ErbB) family receptor tyrosine kinases, most notably that of ErbB2 and ErbB1, have been implicated in the molecular pathogenesis of intrahepatic cholangiocarcinoma. Constitutive overexpression of ErbB2 and/or ErbB1 in malignant cholangiocytes has raised interest in the possibility that agents which selectively target these receptors could potentially be effective in cholangiocarcinoma therapy. However, current experience with such ErbB-directed therapies have at best produced only modest responses in patients with biliary tract cancers. This review provides a comprehensive and critical analysis of both preclinical and clinical studies aimed at assessing the role of altered ErbB2 and/or ErbB1 expression, genetic modifications, and dysregulated signaling on cholangiocarcinoma development and progression. Specific limitations in experimental approaches that have been used to assess human cholangiocarcinoma specimens for ErbB2 and/or ErbB1 overexpression and gene amplification are discussed. In addition, current rodent models of intrahepatic cholangiocarcinogenesis associated with constitutive ErbB2 overexpression are reviewed. Select interactive relationships between ErbB2 or ErbB1 with other relevant molecular signaling pathways associated with intrahepatic cholangiocarcinoma development and progression are also detailed, including those linking ErbB receptors to bile acid, cyclooxygenase-2,interleukin-6/gp130, transmembrane mucins, hepatocyte growth factor/Met, and vascular endothelial growth factor signaling. Lastly, various factors that can limit therapeutic efficacy of ErbB-targeted agents against cholangiocarcinoma are considered. | Alphonse E Sirica | 2008 | World Journal of Gastroenterology2008，14，46： | 34 |
| 2 | JAK-STAT pathway in carcinogenesis:Is it relevant to cholangiocarcinoma progression?显示文摘The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes, cholangiocarcinoma predisposition and development. Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinoma development. | Olga V Smirnova Tatiana Yu Ostroukhova Roman L Bogorad | 2007 | World Journal of Gastroenterology2007，13，48： | 14 |
| 3 | 姜黄素对大肠癌细胞抑制作用Notch信号通路的研究进展显示文摘大肠癌是人类最常见的恶性肿瘤之一,近年来随着人们生活习惯和饮食结构的改变,我国大肠癌的发病率和病死率迅速增长且发病年龄明显提前。目前我国大肠癌中位发病年龄为58岁,比欧美国家提前12—18年”。大肠癌传统治疗有外科手术、放化疗等。化疗虽可有效控制肿瘤的发展,但其明显降低患者生存质量的毒副作用不可小觑,并迫使我们把目光投向毒副作用小的天然药物研究。 | 刘少琼 杨芳 禹正杨 | 2013 | 湖南中医杂志2013，29，12： | 2 |
| 4 | 黏蛋白与肝内胆管癌的研究进展显示文摘肝内胆管癌是原发于胆管上皮细胞的恶性肿瘤,其恶性程度高,预后不佳。而黏蛋白基因的异常表达与胆管癌的发生,进展和预后有着密切的关系。 | 贺彦宇 彭创 | 2011 | 湘南学院学报(医学版)2011，13，3： | 0 |
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