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| 1 | 溃疡性结肠炎患者小肠黏膜病变研究显示文摘目的探讨溃疡性结肠炎患者小肠黏膜病变情况。方法 30例溃疡性结肠炎和25例健康体检者分别作为观察组和对照组,应用胶囊内镜检查评估两组间小肠病变的差异,并分析胶囊内镜检查评分与溃疡性结肠炎疾病活动指数的相关关系。结果 30例溃疡性结肠炎患者中,16例有小肠病变,9例有糜烂,明显高于对照组的5例与1例(P<0.05)。胶囊内镜检查评分与溃疡性结肠炎疾病活动指数呈正相关(r=0.861,P<0.01)。结论溃疡性结肠炎是一种慢性炎症性肠道疾病,不仅局限于结直肠黏膜病变,也可累及小肠。 | 冯波 庄裕梅 | 2013 | 山西医科大学学报2013，44，6： | 1 |
| 2 | Gastroduodenitis associated with ulcerative colitis:A case report显示文摘BACKGROUND Ulcerative colitis(UC)is defined as a chronic inflammatory bowel disease that can occur in any part of the large bowel.In addition,UC affects only the large bowel except for backwash ileitis and pouchitis,whereas Crohn’s disease(CD)affects the entire digestive tract.Inflammatory bowel disease(IBD)patients tend to be diagnosed with CD or indeterminate colitis when combined with gastric lesion.However,in recent years,some UC patients are reported to have various degrees of lesions in gastroduodenum.Here,we report a case of gastroduodenitis associated with UC(GDUC).CASE SUMMARY A 25-year-old man with a history of Klippel-Trenaunay syndrome presented to the hospital with mucopurulent bloody stool and epigastric persistent colic pain for 2 wk.Continuous superficial ulcers and spontaneous bleeding were observed under colonoscopy.Subsequent gastroscopy revealed mucosa with diffuse edema,ulcers,errhysis,and granular and friable changes in the stomach and duodenal bulb,which were similar to the appearance of the rectum.After ruling out other possibilities according to a series of examinations,a diagnosis of GDUC was considered.The patient hesitated about intravenous corticosteroids,so he received a standardized treatment with pentasa of 3.2 g/d.After 0.5 mo of treatment,the patient’s symptoms achieved complete remission.Follow-up endoscopy and imaging findings showed no evidence of recurrence for 26 mo.CONCLUSION The occurrence of gastrointestinal involvement in UC is rare,which may open a new window for studying the etiology and pathogenesis of UC.Physicians should consider broad differential diagnosis by endoscopic biopsy and laboratory examinations. | Ye Yang Chun-Qiang Li Wu-Jie Chen Zhen-Hua Ma Gang Liu | 2020 | World Journal of Clinical Cases2020，8，17： | 1 |
| 3 | 溃疡性结肠炎相关性胃十二指肠病变患者临床特征分析显示文摘目的探讨溃疡性结肠炎相关性胃十二指肠病变(GDUC)患者的临床特征。方法采用描述性病例系列研究方法。回顾性收集2016年1月至2020年12月北京协和医院诊治的6例GDUC患者的临床资料并分析临床特征。结果男性3例,女性3例;溃疡性结肠炎(UC)的发病年龄32.1(20.0~51.0)岁,GDUC的发病年龄36.5(25.0~51.0)岁;UC发病至累及上消化道的时间为4.4(0~12.0)年。UC发病时病变范围E2型(左半结肠)2例,E3型(广泛结肠)4例,改良Mayo评分9.2(8.0~12.0)分。出现GDUC时,改良Mayo评分9.8(8.0~12.0)分,病变累及胃3例,十二指肠受累6例,未见食管受累。2例患者在肠道手术后出现上消化道受累表现。5例患者存在至少1种肠外表现。超敏C-反应蛋白43.2(15.9~77.0)mg/L,红细胞沉降率41.7(12.0~74.0)mm/1 h,血红蛋白108.2(80.0~117.0)g/L。胃镜下表现为胃弥漫性充血、水肿;十二指肠弥漫性充血、点状糜烂等。结肠镜显示,病变范围E2型1例,E3型4例,Mayo内镜评分3分。1例在结直肠切除+回肠储袋肛管吻合+回肠造口术后经结肠镜提示储袋炎。6例患者均应用糖皮质激素诱导缓解,其中2例病情反复后应用英夫利西单克隆抗体诱导缓解并维持治疗,4例缓解期接受免疫抑制剂维持治疗。6例患者随访2.5(0.5~3.5)年,上消化道病变完全缓解4例,部分缓解2例;改良Mayo评分2.8(0~7.0)分。上消化道病变与结肠炎活动度均下降,两者活动度平行。结论GDUC患者具有起病年龄轻、病情重度活动、广泛结肠炎、伴随肠外表现的临床特点,升级治疗后上消化道炎症程度与结肠炎活动度均下降。 | 宋慧 李玥 周炜洵 石钰洁 徐蕙 钱家鸣 | 2022 | 中华炎性肠病杂志(中英文)2022，6，4： | 0 |
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