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| 1 | Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases显示文摘Helicobacter pylori(H. pylori) is an ancient microorganism that has co-evolved with humans for over 60000 years. This bacterium typically colonizes the human stomach and it is currently recognized as the most common infectious pathogen of the gastroduodenal tract. Although its chronic infection is associated with gastritis, peptic ulcer, dysplasia, neoplasia, MALT lymphoma and gastric adenocarcinoma, it has been suggested the possible association of H. pylori infection with several extragastric effects including hepatobiliary and pancreatic diseases. Since a microorganism resembling H. pylori was detected in samples from patients with hepatobiliary disorders, several reports have been discussed the possible role of bacteria in hepatic diseases as hepatocellular carcinoma, cirrhosis and hepatic encephalopathy, nonalcoholic fatty liver disease and fibrosis. Additionally, studies have reported the possible association between H. pylori infection and pancreatic diseases, especially because it has been suggested that this infection could change the pancreatic physiology. Some of them have related a possible association between the microorganism and pancreatic cancer. H. pylori infection has also been suggested to play a role in the acute and chronic pancreatitis pathogenesis, autoimmune pancreatitis, diabetes mellitus and metabolic syndrome. Considering that association of H. pylori to liver and pancreas diseases needs further clarification, our work offers a review about the results of some investigations related to the potential pathogenicity of H. pylori in these extragastric diseases. | Elizabeth MA Rabelo-Goncalves Bruna M Roesler Jose MR Zeitune | 2015 | World Journal of Hepatology2015，7，30： | 16 |
| 2 | 幽门螺杆菌感染对胃外疾病的影响显示文摘幽门螺杆菌(Helicobacter pylori,H.pylori)在胃内定植及其相关致病作用的发现是现代胃肠病学一个重要的里程碑.近30年的研究表明,许多上消化道疾病,如慢性胃炎、消化性溃疡、胃癌和胃黏膜相关淋巴组织淋巴瘤的自然史都与这种细菌的存在有关.此外,H.pylori常参与一些胃外疾病致病过程,特别是那些以持续性、低度系统性炎症为特征的疾病.其可能机制为低等级炎症状态的诱导和分子模拟机制等.本文就H.pylori感染与胃外疾病,如自身免疫性疾病、肿瘤性疾病、心血管疾病及其他相关疾病之间的关系,及可能的机制作一简单综述. | 程灿 李昌平 | 2016 | 世界华人消化杂志2016，24，13： | 8 |
| 3 | 慢性丙型肝炎患者幽门螺杆菌感染及其相关因素分析显示文摘目的:探讨幽门螺杆菌(H pylori)在慢性丙型肝炎中的作用.方法:采用H pylori流行病学诊断标准检测血清anti-H pylori-IgG,来判定是否存在H pylori感染,实时荧光定量聚合酶链反应(FQ-PCR)方法检测血清中HCV RNA的含量,聚合酶链反应-微板核酸杂交-酶联免疫测定法检测血清中HCV基因型.结果:H pylori感染率在慢性丙型肝炎组、丙型肝炎肝硬化组和合并肝癌组明显高于健康对照组(55.5%、76.5%、78.6%vs 43.4%,P<0.05),且随着病变程度的加重,H pylori感染率增加.不同HCV载量的慢性丙型肝炎患者H pylori感染率均增加.基因1a型、1b型、2a型和2b型患者H pylori感染率分别为59.5%、66.7%、65.0%和59.2%,各基因型之间比较无显著性差异.结论:慢性丙型肝炎患者幽门螺杆茵感染率明显增加,H pylori在慢性丙型肝炎向肝硬化和肝癌的发展过程中可能与HCV发挥协同作用. | 季尚玮 张永贵 王江滨 | 2008 | 世界华人消化杂志2008，16，5： | 6 |
| 4 | 幽门螺杆菌与消化系统癌症显示文摘幽门螺杆菌属于革兰氏阴性细菌,被世界卫生组织列为I型致癌物。幽门螺杆菌的高流行率被认为是重要的公共卫生问题,该菌可在世界范围内超过50%的成年人胃上皮细胞中定殖。消化系统癌症是全球常见的癌症,每年造成重大的经济损失,目前的研究表明,幽门螺杆菌与消化系统癌症相关。本综述汇总幽门螺杆菌常见的毒力基因、诊断方法及该菌与消化系统癌症的关系的研究进展,旨在为消化系统癌症的早期诊断奠定基础,也为消化系统癌症诊断标记物的筛选提供思路。 | 彭世宇 高峰 | 2021 | 现代消化及介入诊疗2021，26，4： | 5 |
| 5 | 螺旋杆菌与胆管癌的关系显示文摘幽门螺旋杆菌(HP)已被世界卫生组织列为胃癌的第一致癌原,全世界近半数人群有感染史。近年来的研究表明,螺旋杆菌感染与多种其他部位的肿瘤有关。从螺旋杆菌的分类及流行病学、螺旋杆菌与肝胆肿瘤的关系和螺旋杆菌诱导肿瘤发生的机制3个方面介绍螺旋杆菌感染与肝内外胆管肿瘤的研究现状,为进一步探索肿瘤的病因及诊断治疗提供参考,以期待能改善与提高螺杆菌引起胆管癌的诊治与预后。 | 苑博 李建功 成雨 | 2018 | 临床肝胆病杂志2018，34，2： | 4 |
| 6 | 幽门螺杆菌与胃肠道和胃肠道外肿瘤相关性的研究进展显示文摘幽门螺杆菌(Helicobacter pylori,H.pylori)已被列为明确致癌物,其感染率高、致病性强,显著增加胃黏膜癌前病变的发生风险,是慢性胃炎、消化性溃疡病和胃癌的主要病因,其所导致的诸多疾病也是我国社会和家庭沉重的卫生保健负担。近期研究亦发现H.pylori与结肠癌、食管癌等胃肠道肿瘤,以及胃肠道外癌症(如肝癌、胰腺癌、肺癌等)具有相关性。本综述将汇总与癌症相关性的研究进展,旨在为相关肿瘤的早筛、早诊、早防、早治提供新的思路。 | 王元辰 丁松泽 杜奕奇 李兆申 | 2022 | 健康体检与管理2022，3，3： | 1 |
| 7 | 原发性肝癌组织中螺杆菌属16SrRNA基因的检测及意义显示文摘目的探讨原发性肝癌(HCC)组织中螺杆菌感染情况。方法选取经病理诊断的28例HCC患者的肝癌组织为实验组,22例非肝癌肝病患者肝组织和25例胃癌患者胃癌组织作对照组。采用聚合酶链反应(PCR)扩增螺杆菌属16S rRNA基因、幽门螺杆菌相关功能基因空泡毒素基因(vacA)和细胞毒素相关基因(cagA),16S rRNA的扩增产物经Southern杂交确认,并将PCR产物进行测序及同源性比较。结果28例HCC标本中有17例检出螺杆菌属16S rRNA基因,阳性率为60.7%;25例胃癌标本有18例检出螺杆菌16S rRNA,阳性率为72.0%;其他肝病组未扩增出16S rRNA基因。16S rRNA PCR产物经Southern杂交证实为幽门螺杆菌。序列测定表明,肝癌和胃癌组织中的螺杆菌16S rRNA序列与幽门螺杆菌序列有97.8%的同源性。肝癌组相关功能基因有3例cagA基因阳性,胃癌组有2例cagA基因阳性,均未扩增出vacA基因。提示,幽门螺杆菌菌株的基因型多为Ⅱ型,而少数为Ⅰ型。结论HCC患者肝组织中存在螺杆菌感染且感染率较高。螺杆菌感染与HCC可能存在相关性。 | 宣世英 李宁 战淑慧 强新 | 2006 | 中华传染病杂志2006，24，6： | 1 |
| 8 | Significance of hepatitis B virus surface antigen, hepatitis C virus expression in hepatocellular carcinoma and pericarcinomatous tissues显示文摘AIM: To investigate the correlation between hepatitis B virus surface antigen (HBsAg), hepatitis C virus (HCV) expression in hepatocellular carcinoma (HCC), the HAI score of the noncancerous region of the liver and the serum Alpha fetoprotein (AFP) level.METHODS: The patterns of HBsAg and HCV in 100 cases of HCC and their surrounding liver tissues were studied on paraffin-embedded sections with immuno-histochemistry, the histological status was determined by one pathologist and one surgeon simultaneously using the hepatitis activity index (HAI) score, and AFP was detected by radioimmunity. The study included 100 consecutive patients who underwent curative resection for HCC. Based on HBsAg and HCV expression, the patients were classified into 4 groups: patients positive for HBsAg (HBsAg group), patients positive for HCV (HCV group), patients negative for both HCV and HBsAg (NBNC group) and patients positive for both HBsAg and HCV (BC group).RESULTS: The BC group had significantly higher HAI scores than the other three groups. (BC > HCV > HBsAg > NBNC). HBV and HCV virus infection was positively correlated with HAI (rs = 0.39, P = 0.0001). The positive rate of AFP (85.7%) and the value of AFP (541.2 ng/mL) in the group with HBV and HCV co-infection were the highest among the four groups. The positive rate (53.3%) of AFP and the value of AFP ( 53.3 ng/mL) in the group with none-infection of HBV and HCV were the lowest. HBV and HCV virus infection was positively correlated with AFP(rs = 0.38, P = 0.0001). CONCLUSION: The AFP increase in patients with liver cancer was positively correlated with the infection of HBV and HCV. The serum AFP elevation by the infection of HBV and HCV is one of mechanisms which lead to hepatocarcinogenesis, and the antivirus intervening treatment of hepatitis is significant for the prognosis of liver cancer. From our Spearman’s rank correlation analysis, we can conclude that the severity of virally induced inflammation is correlated with HBsAg and HCV expression in HCC tissues and noncancerous tissues. Prior co-infection of HBV in HCV patients may be an adverse risk factor for intrahepatic inflammation. | Shi-Ying Xuan Yong-Ning Xin Hua Chen Guang-Jun Shi Hua-Shi Guan Yang Li | 2007 | World Journal of Gastroenterology2007，13，12： | 1 |
| 9 | 螺杆菌感染与肝癌关系的Meta分析显示文摘通过数据库检索发表的相关文献,运用Revman5.0对所纳入的文献关于螺杆菌感染与肝癌关系的病例对照研究结果进行定量综合分析。观察组肝癌病例中螺杆菌感染率为52.53%,其对照组螺杆菌感染率仅为9.96%,纳入的9个研究不存在异质性,选择固定效应模型进行Meta分析,估计合并0R值14.19,95%CI(7.92~15.14)。作漏斗图和失安全系数分析结果均表明不存在发表偏倚小,结果可靠。肝癌与螺杆菌感染有关,螺杆菌是肝癌的危险因素。 | 李俊燕 林泉峰 赖宇 | 2016 | 现代诊断与治疗2016，27，22： | 0 |
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