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| 1 | 胃粘膜保护剂的研究进展显示文摘消化性溃疡的治疗不仅要针对攻击因子,增强粘膜保护因子同样不容忽视。近年来胃粘膜保护剂的作用逐渐受到重视,其不仅能使损伤的粘膜上皮修复,还能使粘膜下组织结构修复和重建,从而提高溃疡愈合质量,降低复发率。合理选择和使用粘膜保护剂对巩固疗效,防止溃疡复发有重要意义。 | 朱国琴 施瑞华 | 2006 | 国际消化病杂志2006，26，5： | 23 |
| 2 | 芦荟和白及创面愈合的药理作用比较显示文摘芦荟与白及均为传统中药,临床应用广泛,二者均具有抗菌、消肿生肌、修复组织损伤、促进创面愈合等作用。近年来,人们对其作用机制进行了大量的研究,二者作用机制同中有异。文章就近几年文献记载芦荟与白及应用于各种创伤愈合的药理作用进行了综述,并对其作用机制的异同进行了简单的比较与分析。 | 俞林花 史海霞 聂绪强 卞卡 | 2010 | 时珍国医国药2010，21，6： | 18 |
| 3 | 从代谢组学的角度探讨维胃方对大鼠实验性胃溃疡的疗效机制显示文摘目的从代谢组学的角度探讨维胃方对大鼠实验性胃溃疡的疗效机制。方法采用乙酸灼烧法制备大鼠胃溃疡模型;采用气相色谱-质谱联用仪(GC-MS)获得正常对照组、模型组、自愈组与维胃方治疗组的大鼠胃黏膜匀浆代谢物谱。经数据前处理后,进行偏最小二乘法判别分析(PLS-DA),寻找表征正常对照组与模型组差异的生物标记物;使用主成分分析(PCA)考察维胃方对胃溃疡的治疗效果,并根据生物标记物的变化解释其作用机制。结果模型组与正常对照组的胃黏膜代谢物谱差异有统计学意义;生物标记物包括有机酸、脂肪酸、氨基酸等物质,表明胃溃疡大鼠的胃黏膜出现能量代谢与物质代谢异常;维胃方通过调节胃黏膜的代谢功能,达到有效治疗胃溃疡的目的。结论运用代谢组学技术从整体上揭示了维胃方对大鼠实验性胃溃疡的疗效机制,凸显了中药多靶点综合治疗的特色。 | 彭树灵 刘晓伟 张真瑞 杨健 贺红燕 肖卫平 | 2010 | 中国中西医结合杂志2010，30，10： | 13 |
| 4 | 芦荟多糖对阿司匹林致小鼠胃溃疡的预防作用显示文摘目的:研究芦荟多糖对阿司匹林致小鼠胃溃疡的预防作用.方法:采用阿司匹林灌胃造成小鼠慢性胃溃疡损伤模型,将小鼠随机分为6组:正常对照组、模型组、芦荟多糖低、中、高剂量预处理组、硫糖铝预处理组.分别测定各组小鼠的胃粘膜溃疡指数,计算溃疡发生率及溃疡抑制率,并观察大体及显微镜下组织学变化,以评价阿司匹林致胃溃疡损伤程度及芦荟多糖的预防保护效果.结果:不同浓度的芦荟多糖预处理组与模型组比较,胃粘膜溃疡指数明显下降,差异具有统计学意义(P<0.05),呈剂量相关性,浓度越高,溃疡指数越低,溃疡抑制率越高.与硫糖铝保护组相比,尽管低、中、高剂量芦荟多糖组小鼠的胃粘膜溃疡指数下降更加明显,但差异无统计学意义(P>0.05).结论:芦荟多糖预处理对阿司匹林所致的小鼠胃溃疡有明显的预防保护作用,且其保护作用与硫糖铝相当. | 刘文杰 王耀辉 陈桂星 曾婷婷 陈雪曼 杨思思 臧颖 | 2017 | 转化医学电子杂志2017，4，3： | 7 |
| 5 | 芦荟在皮肤美容中的应用研究进展显示文摘芦荟含有丰富的化学成分,具有多样的药理及临床作用。文章根据近10余年的中外文献,介绍了芦荟的化学成分、药理及临床作用并集中阐述了芦荟在皮肤美容方面的应用研究进展。 | 石宇 李德如 阎国富 | 2007 | 中国中西医结合皮肤性病学杂志2007，6，2： | 6 |
| 6 | Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial显示文摘OBJECTIVE: To investigate the use of Aloe vera(A.vera) for the treatment of gastroesophageal reflux disease(GERD) symptoms and compare its effects with those of omeprazole and ranitidine.METHODS: In this pilot, randomized controlled trial, 79 subjects were allocated to A. vera syrup(standardized to 5.0 mg polysaccharide per m L of syrup)at a dose of 10 m L/d, omeprazole capsule(20 g/d)or ranitidine tablet(150 mg in a fasted state in the morning and 150 mg 30 min before sleep at night)for a period of 4 weeks. The frequencies of eight main symptoms of GERD(heartburn, food regurgitation, flatulence, belching, dysphagia, nausea,vomiting and acid regurgitation) were assessed at weeks 2 and 4 of the trial.RESULTS: A. vera was safe and well tolerated and reduced the frequencies of all the assessed GERD symptoms, with no adverse events requiring withdrawal.CONCLUSION: A. vera may provide a safe and effective treatment for reducing the symptoms of GERD. | Yunes Panahi Hossein Khedmat Ghasem Valizadegan Reza Mohtashami Amirhossein Sahebkar | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 5 |
| 7 | 硫糖铝对上消化道黏膜涂抹的研究显示文摘硫糖铝(sucralfate)作为细胞保护药物被广泛应用于治疗胃食管反流性疾病、消化性溃疡及慢性胃炎的防治中。硫糖铝片剂崩解度差,为提高药效,多改为硫糖铝咀嚼片或硫糖铝水性悬液。本文通过研究三种不同剂型硫糖铝对上消化道黏膜的涂抹情况,为临床用药提供理论依据。 | 刘隽 李诚 张俊美 王爱平 刘嵬 | 2008 | 中华消化杂志2008，28，11： | 3 |
| 8 | 芦荟多糖对大鼠脑缺血c-fos蛋白表达的影响显示文摘目的:观察芦荟多糖抗大鼠脑缺血作用及机制。方法:制备大鼠脑缺血模型,观察芦荟多糖对大鼠脑缺血的行为学及对大脑皮质细胞c-fos凋亡蛋白的影响。结果:芦荟多糖改善大鼠脑缺血的行为学、抑制大脑皮质细胞c-fos蛋白表达。结论:芦荟多糖抑制c-fos的蛋白表达,具有保护大鼠脑缺血作用。 | 朱丹 苏慧 白云 吴童 赵鑫 王怀刚 苏云明 | 2011 | 中医药学报2011，39，5： | 3 |
| 9 | Curcumin prevents indomethacin-induced gastropathy in rats显示文摘AIM:To investigate the effects of curcumin on gastric microcirculation and inflammation in rats with indomethacin-induced gastric damage.METHODS:Male Sprague-Dawley rats were randomly divided into three groups.Group 1(control group,n =5)was fed with olive oil and 5%NaHCO3-(vehicle).Group 2[indomethacin(IMN)group,n=5]was fed with olive oil 30 min prior to indomethacin 150 mg/kg body weight(BW)dissolved in 5%NaHCO3-at time 0th and 4th h.Group 3(IMN+Cur group,n=4)was fed with curcumin 200 mg/kg BW dissolved in olive oil 0.5 mL,30 min prior to indomethacin at 0th and 4th h.Leukocyte-endothelium interactions at postcapillary venules were recorded after acridine orange injection.Blood samples were determined for intercellular adhesion molecule(ICAM)-1 and tumor necrosis factor(TNF)-αlevels using enzyme linked immunosorbent assay method.Finally,the stomach was removed for histopathological examination for gastric lesions and grading for neutrophil infiltration.RESULTS:In group 2,the leukocyte adherence in postcapillary venules was significantly increased compared to the control group(6.40±2.30 cells/frame vs 1.20±0.83 cells/frame,P=0.001).Pretreatment with curcumin caused leukocyte adherence to postcapillary venule to decline(3.00±0.81 cells/frame vs 6.40 ±2.30 cells/frame,P=0.027).The levels of ICAM-1 and TNF-αincreased significantly in the indomethacintreated group compared with the control group(1106.50 ±504.22 pg/mL vs 336.93±224.82 pg/mL,P=0.011 and 230.92±114.47 pg/mL vs 47.13±65.59 pg/mL,P =0.009 respectively).Pretreatment with curcumin significantly decreased the elevation of ICAM-1 and TNF-α levels compared to treatment with indomethacin alone(413.66±147.74 pg/mL vs 1106.50±504.22 pg/mL,P =0.019 and 58.27±67.74 pg/mL vs 230.92±114.47 pg/mL,P=0.013 respectively).The histological appearance of the stomach in the control group was normal.In the indomethacin-treated group,the stomachs showed a mild to moderate neutrophil infiltration score.Gastric lesions were erosive and ulcerative.In rats treated with indomethacin and curcumin,stomach histopathology improved and showed only a mild neutrophil infiltration score and fewer erosive lesions in the gastric mucosa.CONCLUSION:The results indicate that curcumin prevents indomethacin-induced gastropathy through the improvement of gastric microcirculation by attenuating the level of ICAM-1 and TNF-α. | Duangporn Thong-Ngam Sakonwan Choochuai Suthiluk Patumraj Maneerat Chayanupatkul Naruemon Klaikeaw | 2012 | World Journal of Gastroenterology2012，18，13： | 3 |
| 10 | 胃康胶囊治疗非甾体类抗炎药相关性胃溃疡的疗效分析显示文摘非甾体类抗炎药(non-steroidal anti-inflammatory drugs,NSAIDs)是引起消化性溃疡的一种常见病因[1],NSAIDs引起的消化性溃疡尤以胃溃疡多见[2]。胃康胶囊治疗非甾体类抗炎药相关性胃溃疡(NSAID-associated gastric ulcer,NSAID-A-GU)疗效明显,但有关胃康胶囊对细胞因子影响的研究非常少。为探讨胃康胶囊对NSAID-A-GU患者细胞因子的影响. | 施富强 蔡旭华 | 2015 | 全科医学临床与教育2015，13，4： | 3 |
| 11 | 针灸促进胃黏膜损伤修复的代谢机制研究进展显示文摘介绍针灸促进胃黏膜损伤修复的代谢机制,重点从针灸在胃黏膜损伤修复的氨基酸代谢、脂代谢、糖代谢等几个方面探讨其机理,认为针灸可通过调节以上3个方面的代谢途径实现胃黏膜修复,并提出代谢组学在中医应用的展望。 | 杨锦兰 谢宇锋 冯军 杨宗保 | 2019 | 中医药导报2019，0，17： | 2 |
| 12 | 活血愈溃汤联合雷贝拉唑治疗气滞血瘀型消化性溃疡45例临床观察显示文摘目的:观察活血愈溃汤联合雷贝拉唑治疗气滞血瘀型消化性溃疡的临床效果。方法:选择90例气滞血瘀型消化性溃疡患者作为研究对象,将其随机分为对照组和观察组各45例。对照组接受雷贝拉唑+阿莫西林+克拉霉素治疗;观察组在此基础上服用活血愈溃汤,两组疗程均为6周。比较两组的临床疗效。结果:观察组临床治疗总有效率高于对照组(P<0.05),观察组不良反应发生率低于对照组(P<0.05)。结论:活血愈溃汤联合雷贝拉唑治疗气滞血瘀型消化性溃疡效果显著,能够明显促进溃疡的愈合,且不良反应较少,值得临床推广使用。 | 罗磊玲 钟志国 叶秋丽 刘文林 | 2016 | 中国民族民间医药2016，25，24： | 2 |
| 13 | 芦荟浓缩汁配方与冷冻干燥工艺的研究显示文摘芦荟冻干粉在食品和化妆品领域中有着广泛的应用,为了提高我国的芦荟粉加工水平,采用正交实验法对芦荟浓缩汁配比和冷冻干燥工艺进行了研究。结果表明:芦荟浓缩汁的最佳配比是:植酸3.0g/L,甘露醇2.0g/L,麦芽糊精为50%,最佳工艺参数为:加热温度为60℃,真空度为50Pa。冷冻干燥后芦荟粉色泽为白色至淡黄色,水分含量小于3.0%。 | 周治德 李桂银 黄勇 | 2011 | 食品科技2011，36，5： | 2 |
| 14 | 硫糖铝对消化性溃疡涂抹研究显示文摘目的通过研究硫糖铝对消化性溃疡涂抹情况,以探讨硫糖铝对消化性溃疡保护作用,为临床用药提供理论依据。方法将24例患者随机分为对照组(慢性浅表性胃炎)和胃溃疡组12例,空腹嚼服硫糖铝。其余24例患者随机分为对照组(慢性浅表性胃炎),十二指肠溃疡组,空腹口服硫糖铝悬液。服药30min后进行胃镜检查,观察硫糖铝对上消化道黏膜涂抹情况。结果与对照组比较,胃溃疡组胃窦部涂抹均匀;十二指肠溃疡组十二指肠球部涂抹均匀。结论硫糖铝向溃疡部位聚集,更好的保护病变处黏膜。 | 刘隽 李诚 杨彩虹 王爱平 刘嵬 张俊美 | 2009 | 中国实用医药2009，4，12： | 1 |
| 15 | 大鼠实验性胃溃疡的代谢组学研究显示文摘目的:探讨大鼠实验性胃溃疡发生与自愈过程中代谢组学的变化及其机制。方法:Wistar雄性大鼠完全随机分为正常组与不同时间模型组;采用乙酸灼烧法制备胃溃疡模型;运用气相色谱-质谱(GC-MS)获得大鼠胃黏膜代谢物谱,进行主成分分析(PCA)及偏最小二乘法判别分析(PLS-DA)进行模式识别。结果:与正常组比较,不同时间模型组胃黏膜代谢物谱发生明显变化;PCA得分图各组区分良好;PLS-DA获得与分组密切相关的代谢标志物包括某些有机酸、氨基酸、脂肪酸与胆固醇;表明大鼠胃溃疡的发生与自愈过程中出现能量代谢及物质代谢异常。结论:从代谢组学的角度揭示了大鼠实验性胃溃疡代谢物谱的动态变化,较全面地阐释了胃溃疡的发生及自愈机制。 | 彭树灵 刘晓伟 张真瑞 杨健 | 2010 | 实用医学杂志2010，26，18： | 1 |
| 16 | 细胞因子与消化性溃疡修复机制研究进展显示文摘 | 冯春善 | 2008 | 右江医学2008，36，2： | 0 |
| 17 | 姜黄素对甲氨蝶呤诱导的大鼠肠病模型的小肠黏膜保护作用研究显示文摘目的探讨姜黄素对甲氨蝶呤诱导的大鼠肠病模型的小肠黏膜保护作用。方法 Wistar大鼠18只随机分为A组(对照组)、B组(甲氨蝶呤组)、C组(甲氨蝶呤+姜黄素组),实验结束时处死大鼠,测定血清D-乳酸、二胺氧化酶(DAO)水平及组织学检查。结果 B组大鼠的血清D-乳酸、DAO水平较A组明显升高,组织学损伤较A组明显加重;C组大鼠的血清D-乳酸、DAO水平较B组明显降低,组织学损伤较B组明显减轻。结论姜黄素对甲氨蝶呤诱导的大鼠肠病模型肠黏膜具有保护作用。 | 陈周峰 黄智铭 | 2012 | 海峡药学2012，24，10： | 0 |
| 18 | 姜黄素对吲哚美辛诱导的大鼠胃病模型胃黏膜保护作用的研究显示文摘目的探讨姜黄素对吲哚美辛诱导的大鼠胃病模型的胃黏膜的保护作用。方法 Wistar大鼠18只随机分为A组(对照组)、B组(吲哚美辛组)、C组(吲哚美辛+姜黄素组)各6只,实验结束时处死大鼠,测定血清细胞间粘附分子-1和肿瘤坏死因子-α水平及组织学检查。结果 B组血清ICAM-1、TNF-α水平较A组明显升高,组织学损伤较A组明显加重;C组血清ICAM-1、TNF-α水平较B组明显降低,组织学损伤较B组明显减轻。结论姜黄素对吲哚美辛诱导的大鼠胃病模型胃黏膜具有保护作用。 | 陈周峰 黄智铭 | 2012 | 浙江实用医学2012，17，5： | 0 |
| 19 | 老年消化性溃疡病的预防及治疗进展显示文摘消化性溃疡是一种常见的慢性全身性疾病,生活中各种因素如幽门螺杆菌的感染、药物作用、生物遗传因素及社会、心理因素等都能诱发及促进病情发展。胃粘膜侵袭因子(如胃酸和胃蛋白酶)的增强或防御因子的(如粘液屏障、粘膜屏障和粘膜血流量等)[1]减弱均可引起。因发生的部位不同可以分为胃溃疡和十二指肠溃疡[2]。随着人口老龄化。 | 范敏 杨超 | 2013 | 航空航天医学杂志2013，24，5： | 0 |
| 20 | Alginate controls heartburn in patients with erosive and nonerosive reflux disease显示文摘AIM:To evaluate the effect of a novel alginate-based compound,Faringel,in modifying reflux characteristics and controlling symptoms.METHODS:In this prospective,open-label study,40 patients reporting heartburn and regurgitation with proven reflux disease(i.e.,positive impedance-pH test/evidence of erosive esophagitis at upper endoscopy) underwent 2 h impedance-pH testing after eating a refluxogenic meal.They were studied for 1 h under basal conditions and 1 h after taking 10 mL Faringel.In both sessions,measurements were obtained in right lateral and supine decubitus positions.Patients also completed a validated questionnaire consisting of a 2-item 5-point(0-4) Likert scale and a 10-cm visual analogue scale(VAS) in order to evaluate the efficacy of Faringel in symptom relief.Tolerability of the treatment was assessed using a 6-point Likert scale ranging from very good(1) to very poor(6).RESULTS:Faringel decreased significantly(P < 0.001),in both the right lateral and supine decubitus positions,esophageal acid exposure time [median 10(25th75th percentil 6-16) vs 5.8(4-10) and 16(11-19) vs 7.5(5-11),respectively] and acid refluxes [5(3-8) vs 1(1-1) and 6(4-8) vs 2(1-2),respectively],but increased significantly(P < 0.01) the number of nonacid reflux events compared with baseline [2(1-3)vs 3(2-5) and 3(2-4) vs 6(3-8),respectively].Percentage of proximal migration decreased in both decubitus positions(60% vs 32% and 64% vs 35%,respectively;P < 0.001).Faringel was significantly effective in controlling heartburn,based on both the Likert scale [3.1(range 1-4) vs 0.9(0-2);P < 0.001] and VAS score [7.1(3-9.8) vs 2(0.1-4.8);P < 0.001],but it had less success against regurgitation,based on both the Likert scale [2.6(1-4) vs 2.2(1-4);P = not significant(NS)] and VAS score [5.6(2-9.6) vs 3.9(1-8.8);P = NS].Overall,the tolerability of Faringel was very good 5(2-6),with only two patients reporting modest adverse events(i.e.,nausea and bloating).CONCLUSION:Our findings demonstrate that Faringel is well-tolerated and effective in reducing heartburn by modifying esophageal acid exposure time,number of acid refluxes and their proximal migration. | Edoardo Savarino Nicola de Bortoli Patrizia Zentilin Irene Martinucci Luca Bruzzone Manuele Furnari Santino Marchi Vincenzo Savarino | 2012 | World Journal of Gastroenterology2012，18，32： | 0 |
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