共被期刊论文引用了3次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitotic crossover- an evolutionary rudiment which promotes carcinogenesis of colorectal carcinoma显示文摘Mitotic crossover is a natural mechanism that is a main source of the genetic variability of primitive organisms.In complex organisms such as mammals,it represents an evolutionary rudiment which persisted as one of the numerous DNA repair mechanisms,and results in the production of homozygous allele combinations in all heterozygous genes located on the chromosome arm distal to the crossover.This event is familiar as loss of heterozygosity,which is one of the key mechanisms responsible for the development and progression of almost all cancers.We propose the hypothesis in which mitotic crossover is a principal source of the increased loss of heterozygosity that leads to the initiation and progression of colorectal carcinoma.The hypothesis could be tested by in vitro inhibition of Rad51 protein,orthotopic grafting of human colon cancer tissue into the gut of mice,and treatment with potential inhibitors.After these procedures,the frequency of mitotic crossover would be estimated.The development of selective inhibitors of mitotic crossover could stop further carcinogenesis of colorectal carcinoma,as well as many other neoplastic events.Loss of heterozygosity is an event responsible for carcinogenesis,its reduction by selective inhibitors of mitotic crossover could have a positive effect on cancer chemoprevention,as well as on growth reduction and a cessation in the progression of earlier developed tumors. | Branislav Rovcanin Ivan Ivanovski Olivera Djuric Dimitrije Nikolic Jelena Petrovic Petar Ivanovski | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | 人类巨细胞病毒感染与结肠癌相关关系的初步研究显示文摘目的探讨HCMV感染与结肠癌的相关关系,为结肠癌的防治提供新思路。方法利用ELISA技术检测结肠癌患者和正常对照组HCMV-IgG及IgM,同时利用PCR技术及免疫组织化学技术检测结肠癌组织及结肠癌癌旁组织HCMVDNA及HCMVpp65抗原的表达情况,并对这些结果进行分析。结果HCMV-IgG阳性率在结肠癌组和正常对照组无显著性差异。结肠癌组HCMV-IgM检出率明显高于正常对照组;HCMVDNA在结肠癌组织及结肠癌癌旁组织的检出率无显著性差异,但HCMVpp65抗原表达在结肠癌组织明显增强,且无年龄组差异,HCMVpp65表达增强主要见于结肠腺癌。结论HCMV感染与结肠癌的发生明显相关,且HCMV导致结肠癌发生有赖于HCMV的复制。 | 汤智勇 陈华 李倩 邓乐方 陈立华 | 2007 | 实用预防医学2007，14，3： | 2 |
| 3 | 逍遥散对肠易激综合征模型大鼠性激素的干预作用显示文摘目的:观察逍遥散对肠易激综合征(IBS)模型大鼠性激素水平变化的影响及调节作用。方法:50只健康成年SD大鼠,雌雄各半,随机分为正常组、模型组、逍遥散高剂量组、逍遥散低剂量组和匹维溴胺组,每组10只。除正常组外,其余各组大鼠采用心理应激联合腹腔注射鸡卵清蛋白法建立IBS模型。造模结束后,正常组和模型组分别给予生理盐水(15 ml/kg.d-1)灌胃,逍遥散高、低剂量组每天分别给予逍遥散高、低剂量(20 g/kg体质量、5 g/kg体质量),匹维溴胺组给予匹维溴胺(15 mg/体质量.d-1),日1次,连续14 d。以放免法检测各组大鼠性激素水平,以甲苯胺蓝染色法观察结肠黏膜肥大细胞(MC)的变化。结果:IBS大鼠性激素水平紊乱,结肠黏膜组织内MC明显增多(P<0.01)。结论:逍遥散能调节IBS大鼠性激素水平紊乱,降低MC活性。 | 石君杰 王海云 徐发莹 金方 宋李亚 | 2011 | 山东中医杂志2011，30，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员