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| 1 | Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the fifth most common cancer, and hepatitis C virus(HCV) infection plays a major role in HCC development. The molecular mechanisms by which HCV infection leads to HCC are varied. HCV core protein is an important risk factor in HCV-associated liver pathogenesis and can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of signaling pathways such as transforming growth factor β(TGF-β), vascular endothelial growth factor(VEGF), Wnt/β-catenin(WNT), cyclooxygenase-2(COX-2) and peroxisome proliferator-activated receptor α(PPARα) by HCV core protein is implicated in the development of HCC. Therefore, it has been suggested that this protein be considered a favorable target for further studies in the development of HCC. In addition, considering the axial role of these signaling pathways in HCC, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HCV-related HCC. | Shahab Mahmoudvand Somayeh Shokri Reza Taherkhani Fatemeh Farshadpour | 2019 | World Journal of Gastroenterology2019，25，1： | 8 |
| 2 | 门静脉高压侧支循环与血管内皮细胞生长因子显示文摘新近发现门静脉高压侧支循环形成与血管内皮细胞生长因子(VEGF)诱导的血管生成有一定的关系,这对传统认为的门静脉压力增高引起被动的血管通道开放的理论提出了挑战.研究提示在门静脉高压动物中VEGF/VEGF-R2 通路促进了门静脉系统侧支血管和高动力循环的形成.从而证实门静脉高压症侧支循环形成不仅归咎于连接门体静脉系统的分支血管, 而且是VEGF依赖的血管生成结果.现就近来这方面研究的文献作一综述. | 邓伟哲 李柏 | 2006 | 世界华人消化杂志2006，14，16： | 6 |
| 3 | 氧化苦参碱联合干扰素治疗儿童慢性乙型肝炎显示文摘目的研究氧化苦参碱联合干扰素治疗儿童慢性乙型肝炎的效果。方法84例慢性乙型肝炎患儿随机分为二组。治疗组采用氧化苦参碱联合干扰素α-2b治疗,对照组予干扰素α-2b,治疗3、6个月后观察肝功能、HBV DNA及HBeAg转阴率变化。结果治疗3和6个月二组临床症状、肝功能均明显改善,治疗组优于对照组(P<0.05,0.01);治疗6个月HBeAg和HBV DNA转阴率治疗组高于对照组(P<0.05,0.01)。结论氧化苦参碱和干扰素联用在改善慢性乙型肝炎患儿肝功能及HBeAg和HBV DNA转阴率方面具有协同作用。 | 宋新文 高海丽 申保生 王宏伟 | 2007 | 实用儿科临床杂志2007，22，13： | 4 |
| 4 | 成纤维细胞生长因子及其受体在器官纤维化中的作用显示文摘成纤维细胞生长因子(fibroblast growth factor,FGF)家族是一类由23个成员组成的蛋白家族,目前在人类基因组中发现了其中18个成员,分别为FGF1~10与FGF16~23,按照其序列同源性及系统发生,分为5种旁分泌亚家族与1种内分泌亚家族。 | 李小溪 常红恩 奈文青 逯培培 余焱林 戴萌 | 2013 | 中华生物医学工程杂志2013，19，2： | 0 |
| 5 | From bed to bench: Which attitude towards the laboratoryliver tests should health care practitioners strike?显示文摘There is a general consensus in re-interpreting the so-called liver function tests in the light of novel discoveries. At the same time, recent evidence favours the use of different laboratory data to assess liver damage, fibrosis or regenerative process, but this point is not always shared. Actually, balancing the need for diagnosis, prognostic evaluation and therapy response of liver disease with a good cost/benefit ratio is very difficult. New tests are probably not needed but the aim should be for better utilization of existing tests to contain the increasing cost of health care. | Giovanni Tarantino | 2007 | World Journal of Gastroenterology2007，13，37： | 0 |
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