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| 1 | 蛋白质组学方法筛选大肠癌临床分期相关蛋白的初步研究显示文摘目的筛选与大肠癌临床分期相关蛋白,为大肠癌分子分期和预后的预测提供依据。方法将不同临床分期大肠癌组织蛋白进行二维凝胶电泳,选择部分差异表达蛋白进行MALDI-TOF质谱分析和生物信息学分析以鉴定差异表达蛋白;应用免疫组织化学S-P方法验证筛选结果。结果建立了不同临床分期大肠癌组织的二维凝胶电泳图谱,其中Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期大肠癌组织平均蛋白质点数分别为970.14±41.01、980.21±32.42、1010.23±43.10、1240.57±34.20;以Ⅰ期大肠癌为参照,Ⅱ期大肠癌差异表达蛋白有52.42±12.01,Ⅲ期大肠癌差异表达蛋白42.54±11.20,Ⅳ期大肠癌差异表达蛋白72.00±15.25。通过进行质谱分析和生物信息学查询,鉴定了显著差异表达的19个蛋白点,其中Ⅱ期、Ⅲ期、Ⅳ期均上调的有3种蛋白,而仅在Ⅳ期中上调的蛋白有1种。AnnexinⅡ和肝型脂肪酸结合蛋白表达的免疫组化检测结果与蛋白质筛选结果基本一致。结论不同临床分期的大肠癌中存在着差异表达蛋白,这些蛋白可能作为大肠癌分子分期和预后的标志物。 | 汤明 曾亮 邓亚平 陈森林 裴海平 李宜雄 | 2007 | 肿瘤基础与临床2007，20，4： | 1 |
| 2 | A systemic review of glutathione S-transferase P1 Ile105Val polymorphism and colorectal cancer risk显示文摘Objectives: To investigate the correlation between glutathione S-transferase P1(GSTP1) Ile105 Val polymorphism and colorectal cancer(CRC) risk.Methods: Studies were identified to investigate the association between GSTP1 Ile105 Val polymorphism and CRC risk. Systematic computerized searches of the PubMed, Chinese National Knowledge Infrastructure, WANFANG and SinoMed were performed. Summary odds ratios(OR) and 95% confidence intervals(95% CI) were used to measure GSTP1 Ile105 Val polymorphisms and CRC risk. Results: A total of 23 retrospective studies were included in the meta-analysis. During all studies including 6,981 cases and 8,977 controls, sample sizes ranged from 146 to 2,144. Overall, the pooled results revealed that Ile105 Val polymorphism was not associated with CRC risk and confused results were found in subgroup analyses. Further meta-analyses were conducted after excluding low-quality studies. GSTP1 Ile105 Val is associated with increased risk of CRC limited in studies with matched control. There was no significant heterogeneity in all genetic comparisons, but heterogeneity existed in subgroup analyses of heterozygous and dominant comparisons. The meta-regression analyses indicated that matched controls were the significant factor influencing between-study heterogeneity in all possible influential factors including published year, ethnicity, source of control, sample size, Hardy-Weinberg equilibrium(HWE) in control and matched controls. Sensitivity analysis revealed the pooled ORs were not changed before and after removal of each single study in all genetic comparisons, indicating the robustness of the results.Conclusions: GSTP1 Ile105 Val might be associated with increased risk of CRC. However, more highquality case-control studies should be performed to confirm the authenticity of our conclusion. | Qi-Bin Song Qi Wang Wei-Guo Hu | 2014 | Chinese Journal of Cancer Research2014，26，3： | 1 |
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