共被期刊论文引用了3次
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| 1 | 低剂量^(12)C^(6+)离子辐照对小鼠胸腺、脾脏细胞周期及DNA损伤的影响显示文摘研究低剂量12C6+离子全身辐照对小鼠胸腺、脾脏细胞周期进程及DNA损伤的影响。以0、10、50、75、100和250mGy12C6+离子全身辐照小鼠,照射后6h处死小鼠,用流式细胞仪检测受辐照小鼠胸腺、脾脏细胞在各细胞周期的百分率,用彗星电泳技术检测受辐照小鼠胸腺脾脏细胞的拖尾率和拖尾长度。所有照射组G0/G1期胸腺细胞百分率明显低于对照组,(p<0.05),10~100mGy照射组S期胸腺细胞百分率显著高于对照组(p<0.01),所有照射组(G2/M)期胸腺细胞百分率明显高于对照组(p<0.05);所有照射组G0/G1期脾细胞百分率明显高于对照组(p<0.01),S期脾细胞百分率显著低于对照组(p<0.05)。彗星电泳结果显示低剂量12C6+离子辐照以剂量依赖的方式引起小鼠胸腺脾脏细胞DNA迁移长度及拖尾率的增加。低剂量的碳离子辐射可促进小鼠胸腺细胞DNA合成,对小鼠脾脏细胞产生抑制作用,使其发生G1期阻滞;同时对胸腺及脾脏细胞造成具有明显剂量效应关系的DNA损伤。 | 赵卫平 张红 王燕玲 李宁 刘斌 武振华 谢漪 郝冀方 刘阳 | 2008 | 辐射研究与辐射工艺学报2008，26，6： | 6 |
| 2 | ^(125)Ⅰ内照射的小鼠血清中5种微量元素水平变化显示文摘对小鼠灌喂含125Ⅰ放射性物质,建立放射性内照射模型,应用原子吸收光谱法测定了低、中、高辐射源剂量组及对照组小鼠血清中Zn、Cu、Fe、Mg、Mn的含量。结果表明,采用辐射源灌喂的小鼠血清中5种微量元素含量均低于没有灌喂辐射源的对照组,5种微量元素的含量随着辐射剂量的增加而降低。结果提示,通过科学膳食补充人体必需微量元素,对于积极防御辐射对机体健康产生的危害极为重要。 | 莫梅英 徐美奕 | 2007 | 广东微量元素科学2007，14，2： | 5 |
| 3 | 低剂量辐射对荷S180肉瘤小鼠肿瘤的抑制作用及信号传导的影响(英文)显示文摘Objective: By studying the influence of low-dose total body irradiation to proliferating cell nuclear antigens (PCNA), epidermal growth factor receptor (EGFR), erythropoietin (EPO) and vascular endothelial growth factor receptor (VEGFR) of tumor tissues in mice bearing S180 sarcoma, to further explore the mechanism of low doses radiation. Methods: S180 sarcoma cells were implanted subcutaneously into 58 male Kunming mice. Randomly these mice were divided into sham-irradiation (S) group and low-dose radiation (LDR) group. 12 days after implantation, the mice in LDR group were once delivered 75 mGy total-body 60Co γ-ray irradiation, while the mice in S group were left without irradiation. Then the mice in LDR group were executed at 6 h (LDR-6h group), 12 h (LDR-12 h group), 24 h (LDR-24 h group), 48 h (LDR-48 h group) and 72 h (LDR-72h group) after irradiation. Tumor tissues were weighed and histological observed. Immunohistochemical staining was used to detect the expression of PCNA, VEGF, EPO and VEGFR of tumor tissues. Results: Though there was no significant difference between LDR group and S group in tumor weight, after irradiation the expression of PCNA and EPO of tumor tissues in LDR group decreased with time. LDR-24h, LDR-48h and LDR-72h groups were all statistically significantly different from S group. The expression of EGFR and VEGFR also decreased, and LDR-24h group was the lowest (P < 0.05). Conclusion: Seventy-two h after low-dose total body irradiation, there was no significant change in tumor size of mice bearing S180 sarcoma. Low-dose total body radiation decreased the expression of PCNA inhibiting tumor growth; reduced the expression of EGFR in tumor tissue impacting the signal transduction of tumor cells. The study also indicated that low-dose total body irradiation, within a certain period of time, can decrease the expression of hypoxia factor EPO and VEGFR, which may improve the situation of tumor hypoxia and radiosensitivity of tumor itself. | Hongsheng Yu Weihua Sun Ning Liu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，10： | 0 |
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