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| 1 | Slow transit constipation: A functional disorder becomes an enteric neuropathy显示文摘慢运输便秘传统地被看作了并且分类机能紊乱。然而,临床、压力计的证据一直在积累那建议大多数在 STC 的活动性改变怎么可能神经病的类型被考虑。另外,进一步的调查显示出那伤寒神经系统的微妙的改变,不是对常规组织学的检查明显,可能在这些病人在场。在现在的文章,我们将讨论这些证据,并且将试着与处于这个病理学的条件记录的大肠的反常运动机能把他们放在关系。 | Gabrio Bassotti Vincenzo Villanacci | 2006 | World Journal of Gastroenterology2006，12，29： | 38 |
| 2 | Consensus statement AIGO/SICCR:Diagnosis and treatment of chronic constipation and obstructed defecation(partⅠ:Diagnosis)显示文摘Chronic constipation is a common and extremely troublesome disorder that significantly reduces the quality of life,and this fact is consistent with the high rate at which health care is sought for this condition.The aim of this project was to develop a consensus for the diagnosis and treatment of chronic constipation and obstructed defecation.The commission presents its results in a 'Question-Answer' format,including a set of graded recommendations based on a systematic review of the literature and evidence-based medicine.This section represents the consensus for the diagnosis.The history includes information relating to the onset and duration of symptoms and may reveal secondary causes of constipation.The presence of alarm symptoms and risk factors requires investigation.The physical examination should assess the presence of lesions in the anal and perianal region.The evidence does not support the routine use of blood testing and colonoscopy or barium enema for constipation.Various scoring systems are available to quantify the severity of constipation;the Constipation Severity Instrument for constipation and the obstructed defecation syndrome score for obstructed defecation are the most reliable.The Constipation-Related Quality of Life is an excellent tool for evaluating the patient's quality of life.No single test provides a pathophysiological basis for constipation.Colonic transit and anorectal manometry define the pathophysiologic subtypes.Balloon expulsion is a simple screening test for defecatory disorders,but it does not define the mechanisms.Defecography detects structural abnormalities and assesses functional parameters.Magnetic resonance imaging and/or pelvic floor sonography can further complement defecography by providing information on the movement of the pelvic floor and the organs that it supports.All these investigations are indicated to differentiate between slow transit constipation and obstructed defecation because the treatments differ between these conditions. | Antonio Bove Filippo Pucciani Massimo Bellini Edda Battaglia Renato Bocchini Donato Francesco Altomare Giuseppe Dodi Guido Sciaudone Ezio Falletto Vittorio Piloni Dario Gambaccini Vincenzo Bove | 2012 | World Journal of Gastroenterology2012，18，14： | 20 |
| 3 | 瞬时受体电位通道A1与5-羟色胺在慢传输型便秘结肠黏膜中表达的意义显示文摘目的探讨瞬时受体电位通道A1(TRPA1)与5-羟色胺(5-HT)在慢传输型便秘(STC)患者结肠黏膜中表达的意义。方法回顾性分析第三军医大学大坪医院2013年3月至2014年3月收治的10例STC患者和2013年12月至2014年5月收治的10例乙状结肠癌患者的临床资料。收集患者手术切除的降结肠标本,其中10例STC患者的降结肠标本为便秘组;10例乙状结肠癌患者的降结肠标本(距肿瘤边缘距离〉10cm)为对照组。采用免疫荧光染色检测对照组结肠黏膜中TRPA1与5-HT的表达情况,免疫组织化学染色检测两组结肠黏膜中TRPA1与5-HT的表达情况,Westernblot检测检测结肠黏膜中TRPA1表达情况。正态分布的计量资料用面±s表示,组问比较采用t检验。结果免疫荧光染色检测结果显示:对照组TRPA1与5-HT共表达于结肠黏膜(肠嗜铬细胞)。免疫组织化学染色检测结果显示:便秘组TRPA1与5-HT表达的IOD值分别为3619±1702、55721±28613;对照组分别为9894±3325、12949±2200,两组比较,差异有统计学意义(t=-5.312,4.713,P〈0.05)。Westernblot检测结果显示:便秘组TRPA1蛋白相对表达量为0.8±0.3,对照组为1.5±0.5,两组比较,差异有统计学意义(t=-2.379,P〈0.05)。结论TRPA1在肠黏膜的肠嗜铬细胞中表达,STC患者降结肠黏膜5-HT表达上调、TRPA1表达下调可能与其发病相关。 | 田跃 刘晓波 童卫东 杨汉勇 王李 刘宝华 | 2015 | 中华消化外科杂志2015，14，3： | 10 |
| 4 | 泻剂结肠大鼠模型阿片受体表达变化显示文摘目的探讨3种阿片受体亚型(MOR、DOR、KOR)在泻剂结肠大鼠模型结肠内的表达变化及意义。方法使用7~8周龄Wistar大鼠20只,体质量(200±20)g,雌雄各半,按随机数字表法分为对照组(n=10)及泻剂结肠组(n=10),单只分笼饲养(环境温度18~28℃,相对湿度40%~80%)。对照组饲以普通饲料,泻剂结肠组饲以含酚酞饲料。通过RT-qPCR及Western blot法对阿片受体在结肠中的表达进行相对定量分析。结果 3种阿片受体亚型在泻剂结肠组及对照组大鼠结肠内均有不同程度的表达。RT-qPCR检测显示泻剂结肠组MOR、DOR及KOR mRNA相对表达水平均明显高于对照组[(5.093±1.410)vs(1.092±0.222),(2.612±0.612)vs(1.032±0.082),(2.607±0.327)vs(0.995±0.109),P〈0.01]。Western blot检测显示泻剂结肠组MOR、DOR及KOR的表达较对照组明显升高[(0.361±0.023)vs(0.152±0.021),(0.246±0.059)vs(0.159±0.005),(0.309±0.018)vs(0.201±0.015),P〈0.01]。结论各阿片受体亚型在泻剂结肠大鼠结肠中表达均明显增强,提示其对泻剂结肠大鼠结肠运动及分泌功能可能存在明显的抑制作用。 | 吴劲松 刘宝华 童卫东 李凡 张安平 付涛 李春穴 | 2013 | 第三军医大学学报2013，35，21： | 1 |
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